Combination Therapy with Gallium Protoporphyrin and Gallium Nitrate Exhibits Enhanced Antimicrobial Activity

Animals Mice Methicillin-Resistant Staphylococcus aureus Protoporphyrins / pharmacology Staphylococcus aureus Tissue Distribution Anti-Bacterial Agents / pharmacology Gallium / pharmacology Heme / metabolism Iron / metabolism Microbial Sensitivity Tests
MRSA combination gallium mice small colony variant toxicity

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
07 08 2023
Historique:
medline: 8 8 2023
pubmed: 20 7 2023
entrez: 20 7 2023
Statut: ppublish

Résumé

There is a major need for the development of new therapeutics to combat antibiotic-resistant

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c00223 PMID: 37471668
pubmed: 37471668
doi: 10.1021/acs.molpharmaceut.3c00223
doi:

Substances chimiques

Protoporphyrins 0
gallium nitrate VRA0C6810N
Anti-Bacterial Agents 0
Gallium CH46OC8YV4
Heme 42VZT0U6YR
Iron E1UOL152H7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4058-4070

Auteurs

Seoung-Ryoung Choi (SR)

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
ORCID: 0000-0003-4874-559X

Geoffrey A Talmon (GA)

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Kenneth Hearne (K)

Aridis Pharmaceuticals, Los Gatos, California 95032, United States.

Jennifer Woo (J)

Aridis Pharmaceuticals, Los Gatos, California 95032, United States.

Vu L Truong (VL)

Aridis Pharmaceuticals, Los Gatos, California 95032, United States.

Bradley E Britigan (BE)

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Department of Internal Medicine and Research Service, Veterans Affairs Medical Center-Nebraska Western Iowa, Omaha, Nebraska 68105, United States.

Prabagaran Narayanasamy (P)

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
ORCID: 0000-0002-9617-5555

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Combination Therapy with Gallium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Combination Therapy with Gallium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Combination Therapy with Gallium...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Protoporphyrines › Combination Therapy with Gallium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Combination Therapy with Gallium...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Combination Therapy with Gallium...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Combination Therapy with Gallium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Combination Therapy with Gallium...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Combination Therapy with Gallium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Combination Therapy with Gallium...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Combination Therapy with Gallium...