Disability and persistent motor deficits are linked to structural crossed cerebellar diaschisis in chronic stroke.
CCD
atrophy
motor
recovery
stroke
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
15
06
2023
received:
23
04
2023
accepted:
07
07
2023
medline:
3
10
2023
pubmed:
20
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
Brain imaging has significantly contributed to our understanding of the cerebellum being involved in recovery after non-cerebellar stroke. Due to its connections with supratentorial brain networks, acute stroke can alter the function and structure of the contralesional cerebellum, known as crossed cerebellar diaschisis (CCD). Data on the spatially precise distribution of structural CCD and their implications for persistent deficits after stroke are notably limited. In this cross-sectional study, structural MRI and clinical data were analyzed from 32 chronic stroke patients, at least 6 months after the event. We quantified lobule-specific contralesional atrophy, as a surrogate of structural CCD, in patients and healthy controls. Volumetric data were integrated with clinical scores of disability and motor deficits. Diaschisis-outcome models were adjusted for the covariables age, lesion volume, and damage to the corticospinal tract. We found that structural CCD was evident for the whole cerebellum, and particularly for lobules V and VI. Lobule VI diaschisis was significantly correlated with clinical scores, that is, volume reductions in contralesional lobule VI were associated with higher levels of disability and motor deficits. Lobule V and the whole cerebellum did not show similar diaschisis-outcome relationships across the spectrum of the clinical scores. These results provide novel insights into stroke-related cerebellar plasticity and might thereby promote lobule VI as a key area prone to structural CCD and potentially involved in recovery and residual motor functioning.
Identifiants
pubmed: 37471691
doi: 10.1002/hbm.26434
pmc: PMC10543354
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5336-5345Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Radiology. 2017 Oct;285(1):214-222
pubmed: 28777703
Neuroimage. 2017 Feb 15;147:916-924
pubmed: 27833012
Brain. 2010 Apr;133(Pt 4):1224-38
pubmed: 20354002
Neuroimage. 2012 Feb 1;59(3):2771-82
pubmed: 22023742
Brain. 2003 Nov;126(Pt 11):2476-96
pubmed: 12937084
Cortex. 2010 Jan;46(1):124-7
pubmed: 19344895
Hum Brain Mapp. 2013 Aug;34(8):1872-81
pubmed: 22431281
Eur J Radiol. 2016 Jan;85(1):136-142
pubmed: 26724658
JAMA Neurol. 2019 Feb 1;76(2):170-178
pubmed: 30476999
Cortex. 2010 Jul-Aug;46(7):831-44
pubmed: 20152963
Neurotherapeutics. 2022 Mar;19(2):491-500
pubmed: 35226342
Neuroimage. 2014 Jul 15;95:217-31
pubmed: 24657354
Cereb Cortex. 2017 Jan 1;27(1):635-645
pubmed: 26508336
Neural Regen Res. 2016 Sep;11(9):1424-1430
pubmed: 27857744
Neuroimage. 2013 Feb 15;67:283-97
pubmed: 23194819
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7699-704
pubmed: 12032346
Neurosci Lett. 2016 Feb 2;613:6-12
pubmed: 26742641
BMC Neurosci. 2020 Nov 20;21(1):46
pubmed: 33218307
Stroke. 2011 May;42(5):1357-62
pubmed: 21441147
J Cereb Blood Flow Metab. 2017 Nov;37(11):3615-3624
pubmed: 28084869
Front Aging Neurosci. 2017 Feb 17;9:10
pubmed: 28261086
Acta Neurol Scand. 2012 Jun;125(6):373-81
pubmed: 21781057
J Neuroimaging. 1999 Jan;9(1):30-3
pubmed: 9922721
Neurorehabil Neural Repair. 2021 Jan;35(1):23-32
pubmed: 33166213
Contrast Media Mol Imaging. 2018 Dec 2;2018:2483078
pubmed: 30627057
J Neurosci. 1999 Feb 15;19(4):1446-63
pubmed: 9952421
J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):174-9
pubmed: 8126499
Neuroimage. 2013 Dec;83:103-19
pubmed: 23792980
Stroke. 1995 Jan;26(1):90-5
pubmed: 7839405
Transl Stroke Res. 2021 Feb;12(1):39-48
pubmed: 32506367
Cerebrovasc Dis. 2023;52(5):552-559
pubmed: 36716718
Cereb Cortex. 2007 Dec;17(12):2980-7
pubmed: 17389628
Front Neural Circuits. 2021 Oct 27;15:655502
pubmed: 34776874
Front Neurol. 2022 Mar 08;13:802113
pubmed: 35345406
Brain Struct Funct. 2015 Sep;220(5):2533-50
pubmed: 24906703
Brain Commun. 2022 Aug 04;4(6):fcac203
pubmed: 36337341
Eur J Neurosci. 2017 Oct;46(7):2308-2314
pubmed: 28833690
Cerebellum. 2020 Feb;19(1):1-5
pubmed: 31707620
J Nucl Med. 1997 Jan;38(1):14-9
pubmed: 8998142
Trends Cogn Sci. 2013 May;17(5):241-54
pubmed: 23579055
Hum Brain Mapp. 2023 Nov;44(16):5336-5345
pubmed: 37471691
Cerebellum. 2018 Jun;17(3):359-371
pubmed: 29243202
Front Neuroinform. 2016 Jul 27;10:30
pubmed: 27512372
Cereb Cortex. 2020 Mar 14;30(3):1330-1344
pubmed: 31647536
Neuropsychologia. 2003;41(3):252-62
pubmed: 12457751
Brain. 2002 Jul;125(Pt 7):1544-57
pubmed: 12077004
Neurorehabil Neural Repair. 2013 Jan;27(1):53-62
pubmed: 22645108
J Cogn Neurosci. 2010 Nov;22(11):2663-76
pubmed: 19925191
Front Hum Neurosci. 2016 Aug 03;10:393
pubmed: 27536229
Cereb Cortex. 2022 Dec 8;32(24):5622-5627
pubmed: 35169830
Front Neurol. 2019 Feb 14;10:105
pubmed: 30837935
Brain Struct Funct. 2017 May;222(4):1929-1944
pubmed: 27699480
Brain. 1986 Aug;109 ( Pt 4):677-94
pubmed: 3488093
J Stroke Cerebrovasc Dis. 2014 Oct;23(9):2378-83
pubmed: 25183560
Trans Am Neurol Assoc. 1981;105:459-61
pubmed: 19645126
Ann Neurol. 2009 May;65(5):596-602
pubmed: 19479972
Stroke. 2004 Feb;35(2):472-6
pubmed: 14739422