Mitochondria during T cell aging.

Humans Reactive Oxygen Species / metabolism T-Lymphocytes / metabolism Mitochondria / genetics Aging / genetics Cellular Senescence
Aging Apoptosis Calcium homeostasis Inflammaging Lymphocyte Mitochondria Mitochondrial dynamics Mitokines Mitophagy MtDNA ROS T cells

Journal

Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458

Informations de publication

Date de publication:
09 2023
Historique:
received: 13 04 2023
revised: 30 06 2023
accepted: 10 07 2023
medline: 21 8 2023
pubmed: 21 7 2023
entrez: 20 7 2023
Statut: ppublish

Résumé

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is characterized by alterations of the mitochondrial DNA, reduced respiratory capacity, decreased mitochondrial membrane potential and increased reactive oxygen species production. These primary alterations disrupt other interconnected and important mitochondrial-related processes such as metabolism, mitochondrial dynamics and biogenesis, mitophagy, calcium homeostasis or apoptosis. In this review, we gather the current knowledge about the different mitochondrial processes which are altered during aging, with special focus on their contribution to age-associated T cell dysfunction and inflammaging.

Identifiants

DOI: 10.1016/j.smim.2023.101808 PMID: 37473558
pubmed: 37473558
pii: S1044-5323(23)00099-4
doi: 10.1016/j.smim.2023.101808
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101808

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Competing interests The authors declare no competing interests.

Auteurs

Jose Ignacio Escrig-Larena (JI)

Consejo Superior de Investigaciones Científicas (CSIC), Centro de Biología Molcular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Sandra Delgado-Pulido (S)

Departamento de Biología Molecular, Facultad de Ciencias (UAM), Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

María Mittelbrunn (M)

Consejo Superior de Investigaciones Científicas (CSIC), Centro de Biología Molcular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid (UAM), Madrid, Spain. Electronic address: mmittelbrunn@cbm.csic.es.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mitochondria during T cell aging.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Mitochondria during T cell aging.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Mitochondria during T cell aging.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondria during T cell aging.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Mitochondria during T cell aging.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Mitochondria during T cell aging.