Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition.
AP-1
DNA damage
Erk
JNK
MAPK
c-Jun
cancer therapy
senescence
senescence-associated secretory phenotype
tensor PLSR
topoisomerase
Journal
Cell systems
ISSN: 2405-4720
Titre abrégé: Cell Syst
Pays: United States
ID NLM: 101656080
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
received:
14
06
2022
revised:
24
03
2023
accepted:
13
06
2023
pmc-release:
19
07
2024
medline:
2
8
2023
pubmed:
21
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
Genotoxic stress in mammalian cells, including those caused by anti-cancer chemotherapy, can induce temporary cell-cycle arrest, DNA damage-induced senescence (DDIS), or apoptotic cell death. Despite obvious clinical importance, it is unclear how the signals emerging from DNA damage are integrated together with other cellular signaling pathways monitoring the cell's environment and/or internal state to control different cell fates. Using single-cell-based signaling measurements combined with tensor partial least square regression (t-PLSR)/principal component analysis (PCA) analysis, we show that JNK and Erk MAPK signaling regulates the initiation of cell senescence through the transcription factor AP-1 at early times after doxorubicin-induced DNA damage and the senescence-associated secretory phenotype (SASP) at late times after damage. These results identify temporally distinct roles for signaling pathways beyond the classic DNA damage response (DDR) that control the cell senescence decision and modulate the tumor microenvironment and reveal fundamental similarities between signaling pathways responsible for oncogene-induced senescence (OIS) and senescence caused by topoisomerase II inhibition. A record of this paper's transparent peer review process is included in the supplemental information.
Identifiants
pubmed: 37473730
pii: S2405-4712(23)00158-8
doi: 10.1016/j.cels.2023.06.005
pmc: PMC10627503
mid: NIHMS1919509
pii:
doi:
Substances chimiques
DNA Topoisomerases, Type II
EC 5.99.1.3
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
582-604.e10Subventions
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA112967
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES028374
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104047
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM068762
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests K.A.J., P.K.S., and D.A.L. are on the Advisory Board of Cell Systems.
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