Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.

Humans beta-Arrestins / metabolism Chemokine CXCL12 / metabolism G-Protein-Coupled Receptor Kinases / metabolism HEK293 Cells Ligands Phosphorylation Protein Binding Receptors, CXCR4 / metabolism

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
10 2023
Historique:
received: 24 04 2023
accepted: 30 06 2023
medline: 18 9 2023
pubmed: 21 7 2023
entrez: 20 7 2023
Statut: ppublish

Résumé

Atypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging process restricts the availability of the chemokine agonist CXCL12 for the G protein-coupled receptor (GPCR) CXCR4 and requires phosphorylation of the ACKR3 C-terminus by GPCR kinases (GRKs). ACKR3 is phosphorylated by GRK2 and GRK5, but the mechanisms by which these kinases regulate the receptor are unresolved. Here we determined that GRK5 phosphorylation of ACKR3 results in more efficient chemokine scavenging and

Identifiants

DOI: 10.1124/molpharm.123.000710 PMID: 37474305
pubmed: 37474305
pii: molpharm.123.000710
doi: 10.1124/molpharm.123.000710
doi:

Substances chimiques

beta-Arrestins 0
Chemokine CXCL12 0
G-Protein-Coupled Receptor Kinases EC 2.7.11.16
Ligands 0
Receptors, CXCR4 0
ACKR3 protein, human 0
CXCR4 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

174-186

Subventions

Organisme : NIGMS NIH HHS
ID : F32 GM137505
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

Copyright © 2023 by The Author(s).

Auteurs

Christopher T Schafer (CT)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (C.T.S., T.M.H.) and Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (Q.C., J.J.G.T.).
ORCID: 0000-0001-9907-295X

Qiuyan Chen (Q)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (C.T.S., T.M.H.) and Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (Q.C., J.J.G.T.).

John J G Tesmer (JJG)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (C.T.S., T.M.H.) and Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (Q.C., J.J.G.T.).

Tracy M Handel (TM)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (C.T.S., T.M.H.) and Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (Q.C., J.J.G.T.) thandel@ucsd.edu jtesmer@purdue.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Arrestines › bêta-Arrestines › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL12 › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Kinases associées à des récepteurs couplés à une protéine G › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Métabolisme › Phosphorylation › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Atypical Chemokine Receptor 3 "Senses" CXC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › Atypical Chemokine Receptor 3 "Senses" CXC...