Preoperative thalamus volume is not associated with preoperative cognitive impairment (preCI) or postoperative cognitive dysfunction (POCD).
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 07 2023
20 07 2023
Historique:
received:
09
09
2022
accepted:
12
07
2023
medline:
2
8
2023
pubmed:
21
7
2023
entrez:
20
7
2023
Statut:
epublish
Résumé
A growing body of literature suggests the important role of the thalamus in cognition and neurodegenerative diseases. This study aims to elucidate whether the preoperative thalamic volume is associated with preoperative cognitive impairment (preCI) and whether it is predictive for postoperative cognitive dysfunction at 3 months (POCD). We enrolled 301 patients aged 65 or older and without signs of dementia who were undergoing elective surgery. Magnetic resonance imaging was conducted prior to surgery. Freesurfer (version 5.3.) was used to automatically segment the thalamus volume. A neuropsychological test battery was administered before surgery and at a 3 month follow-up. It included the computerized tests Paired Associate Learning (PAL), Verbal Recognition Memory (VRM), Spatial Span Length (SSP), Simple Reaction Time (SRT), the pen-and-paper Trail-Making-Test (TMT) and the manual Grooved Pegboard Test (GPT). Using a reliable change index, preCI and POCD were defined as total Z-score > 1.96 (sum score over all tests) and/or Z-scores > 1.96 in ≥ 2 individual cognitive test parameters. For statistical analyses, multivariable logistic regression models were applied. Age, sex and intracranial volume were covariates in the models. Of 301 patients who received a presurgical neuropsychological testing and MRI, 34 (11.3%) had preCI. 89 patients (29.5%) were lost to follow-up. The remaining 212 patients received a follow-up cognitive test after 3 months, of whom 25 (8.3%) presented with POCD. Independently of age, sex and intracranial volume, neither preCI (OR per cm
Identifiants
pubmed: 37474784
doi: 10.1038/s41598-023-38673-x
pii: 10.1038/s41598-023-38673-x
pmc: PMC10359451
doi:
Banques de données
ClinicalTrials.gov
['NCT02265263']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11732Investigateurs
Alissa Wolf
(A)
Anika Müller
(A)
Daniel Hadzidiakos
(D)
Fatima Yürek
(F)
Gunnar Lachmann
(G)
Kwaku Ofosu
(K)
Maria Heinrich
(M)
Rudolf Mörgeli
(R)
Jürgen Gallinat
(J)
Simone Kühn
(S)
Arjen Slooter
(A)
Edwin van Dellen
(E)
Ilse Kant
(I)
Jeroen de Bresser
(J)
Jeroen Hendrikse
(J)
Simone van Montfort
(S)
David Menon
(D)
Emmanuel Stamatakis
(E)
Jacobus Preller
(J)
Laura Moreno-López
(L)
Stefan Winzeck
(S)
Daniela Melillo
(D)
Diana Boraschi
(D)
Giacomo Della Camera
(GD)
Paola Italiani
(P)
Reinhard Schneider
(R)
Roland Krause
(R)
Karsten Heidtke
(K)
Peter Nürnberg
(P)
Anja Helmschrodt
(A)
Axel Böcher
(A)
Bettina Hafen
(B)
Franz Paul Armbruster
(FP)
Ina Diehl
(I)
Jana Ruppert
(J)
Katarina Hartmann
(K)
Marion Kronabel
(M)
Marius Weyer
(M)
Thomas Bernd Dschietzig
(TB)
Malte Pietzsch
(M)
Simon Weber
(S)
Bernd Ittermann
(B)
Ariane Fillmer
(A)
Informations de copyright
© 2023. The Author(s).
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