Fibrosis-the tale of H3K27 histone methyltransferases and demethylases.
EZH1
EZH2
UTX
chromatin
epigenetics
extracellular matrix
fibrosis
myofibroblast
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
24
03
2023
accepted:
22
06
2023
medline:
21
7
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
epublish
Résumé
Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic extracellular matrix (ECM). Currently, there is a lack of effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition of a fibrotic phenotype is associated with changes in chromatin structure, a key determinant of gene transcription activation and repression. The major repressive histone mark, H3K27me3, has been linked to dynamic changes in gene expression in fibrosis through alterations in chromatin structure. H3K27-specific homologous histone methylase (HMT) enzymes, Enhancer of zeste 1 and 2 (EZH1, EZH2), which are the alternative subunits of the Polycomb Repressive Complex 2 (PRC2) and demethylase (KDM) enzymes, Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), and Lysine demethylase 6B (KDM6B), are responsible for regulating methylation status of H3K27me3. In this review, we explore how these key enzymes regulate chromatin structure to alter gene expression in fibrosis, highlighting them as attractive targets for the treatment of fibrosis.
Identifiants
pubmed: 37476157
doi: 10.3389/fcell.2023.1193344
pii: 1193344
pmc: PMC10354294
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1193344Subventions
Organisme : NEI NIH HHS
ID : R01 EY026159
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM075141
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR052273
Pays : United States
Informations de copyright
Copyright © 2023 Basta, Petruk, Mazo and Walker.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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