The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium.
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
13 Mar 2023
13 Mar 2023
Historique:
medline:
21
7
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduces atherosclerotic burden and decreases inflammation. However, Tie2 tyrosine kinase function in atherosclerosis is unknown. Here we provide genetic evidence from humans and from an atherosclerotic mouse model to show that TIE2 is associated with protection from coronary artery disease. We show that deletion of
Identifiants
pubmed: 37476204
doi: 10.1038/s44161-023-00224-y
pmc: PMC7614785
mid: EMS179236
doi:
Types de publication
Journal Article
Langues
eng
Pagination
307-321Déclaration de conflit d'intérêts
Competing interests O.S. is named as a co-inventor on a patent on peptides disrupting chemokine heteromers (WO2017/077062A1) and two patents on peptides neutralizing extracellular histones (WO2019/122127 A1 and WO2021209465A1). These patents are outside the scope of the current manuscript. O.S. is a scientfic advisor to Novo Nordisk and ResoTher Pharma. The other authors declare no competing interests.
Références
Circulation. 1996 Feb 15;93(4):672-82
pubmed: 8640995
Circ Res. 2018 Jun 8;122(12):1661-1674
pubmed: 29545365
PLoS One. 2011;6(12):e25734
pubmed: 22162987
Circ Res. 2014 May 23;114(11):1684-9
pubmed: 24677271
Am J Pathol. 2005 Sep;167(3):901-12
pubmed: 16127167
Genome Biol. 2019 Jul 8;20(1):133
pubmed: 31287004
Development. 2013 Jul;140(14):3051-61
pubmed: 23785053
Circ Res. 2009 Jun 5;104(11):1302-12
pubmed: 19443835
Circulation. 1997 Sep 16;96(6):1729-32
pubmed: 9323053
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Nat Med. 2009 Jan;15(1):97-103
pubmed: 19122657
Eur Heart J. 2020 Jun 21;41(24):2313-2330
pubmed: 32052833
Nat Immunol. 2019 Feb;20(2):163-172
pubmed: 30643263
Nat Commun. 2015 Jul 22;6:7866
pubmed: 26198319
Nat Genet. 2017 Oct;49(10):1450-1457
pubmed: 28869590
Cardiovasc Res. 2001 Feb 16;49(3):659-70
pubmed: 11166279
J Cell Biol. 2015 Apr 13;209(1):13-22
pubmed: 25869663
Nat Med. 2019 Aug;25(8):1280-1289
pubmed: 31359001
J Cell Biol. 2005 Apr 25;169(2):239-43
pubmed: 15851516
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158535
pubmed: 31678621
Circ Res. 2009 Jun 19;104(12):1333-6
pubmed: 19461044
Cell. 1999 Mar 19;96(6):857-68
pubmed: 10102273
J Clin Invest. 2011 Apr;121(4):1624-35
pubmed: 21383501
Cell Rep. 2015 Sep 22;12(11):1761-73
pubmed: 26344773
Clin Sci (Lond). 2017 Jan 1;131(1):87-103
pubmed: 27941161
Nat Rev Drug Discov. 2021 Aug;20(8):589-610
pubmed: 33976384
Science. 2020 Sep 11;369(6509):1318-1330
pubmed: 32913098
Mediators Inflamm. 2017;2017:8135934
pubmed: 28680196
Gigascience. 2020 Dec 26;9(12):
pubmed: 33367645
Cardiovasc Res. 2017 Jan;113(1):81-89
pubmed: 28069704
Nat Med. 2019 Oct;25(10):1576-1588
pubmed: 31591603
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7
pubmed: 26884170
Nat Commun. 2021 Feb 17;12(1):1088
pubmed: 33597522
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):207-9
pubmed: 19910638
J Atheroscler Thromb. 2011;18(3):209-16
pubmed: 21099169
Circulation. 2019 Jul 9;140(2):147-163
pubmed: 31146585
Nat Commun. 2021 Feb 3;12(1):764
pubmed: 33536417
Circ Res. 2000 Jul 21;87(2):153-9
pubmed: 10904000
Nat Genet. 2017 Sep;49(9):1385-1391
pubmed: 28714975
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Nat Rev Cardiol. 2020 Jan;17(1):52-63
pubmed: 31366922
Genomics Proteomics Bioinformatics. 2022 Jun;20(3):541-548
pubmed: 35643189
Atherosclerosis. 2013 Feb;226(2):356-63
pubmed: 23245509
Circ Res. 2020 Jul 17;127(3):402-426
pubmed: 32673538
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Nat Rev Cardiol. 2021 Jan;18(1):58-68
pubmed: 32918047
Nat Rev Drug Discov. 2017 Sep;16(9):635-661
pubmed: 28529319
J Clin Invest. 2016 Sep 1;126(9):3495-510
pubmed: 27548530
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Am Soc Nephrol. 2017 Jul;28(7):1973-1982
pubmed: 28465380
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Nat Rev Nephrol. 2017 Jun;13(6):368-380
pubmed: 28392564
Nat Genet. 2015 Oct;47(10):1121-1130
pubmed: 26343387
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2946-51
pubmed: 15710889
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12
pubmed: 21930913
Antioxid Redox Signal. 2011 Sep 15;15(6):1607-38
pubmed: 21050132
BMC Genomics. 2011 Oct 14;12:507
pubmed: 21999641
Circulation. 2002 Jun 25;105(25):3025-31
pubmed: 12081998
Cell Syst. 2019 Apr 24;8(4):329-337.e4
pubmed: 30954475
Circ Res. 2018 Feb 2;122(3):433-443
pubmed: 29212778
Circ Res. 2020 Nov 6;127(11):1437-1455
pubmed: 32981416
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
J Clin Invest. 2016 Sep 1;126(9):3511-25
pubmed: 27548529
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Nat Rev Mol Cell Biol. 2009 Mar;10(3):165-77
pubmed: 19234476
Atherosclerosis. 2015 Aug;241(2):297-304
pubmed: 26062989
Nat Rev Dis Primers. 2019 Aug 16;5(1):56
pubmed: 31420554
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Am J Pathol. 2010 Dec;177(6):3233-43
pubmed: 20952594
Circ Genom Precis Med. 2018 Mar;11(3):e001978
pubmed: 29555671
Circ Genom Precis Med. 2020 Jun;13(3):e002670
pubmed: 32469254
Blood. 2020 Jul 30;136(5):627-639
pubmed: 32369573
J Clin Invest. 2001 May;107(10):1255-62
pubmed: 11375415
Cell Metab. 2012 Mar 7;15(3):372-81
pubmed: 22405072
Nat Commun. 2019 Apr 3;10(1):1523
pubmed: 30944313
Trends Cardiovasc Med. 2011 May;21(4):118-23
pubmed: 22681967
Commun Biol. 2022 Oct 12;5(1):1084
pubmed: 36224302
Int J Mol Med. 2013 May;31(5):1066-74
pubmed: 23545584