Phenotypic Variability in Acquired and Idiopathic Dystonia.
acquired
clinical phenomenology
dystonia
idiopathic
Journal
Movement disorders clinical practice
ISSN: 2330-1619
Titre abrégé: Mov Disord Clin Pract
Pays: United States
ID NLM: 101630279
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
21
11
2022
revised:
17
03
2023
accepted:
02
05
2023
pmc-release:
07
06
2024
medline:
21
7
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
epublish
Résumé
To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias. To compare demographic data and clinical features in patients with adult-onset acquired and idiopathic dystonias. Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult-onset dystonia. Study population included 116 patients with adult-onset acquired dystonia and 651 patients with isolated adult-onset idiopathic dystonia. Comparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor. The clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.
Sections du résumé
Background
UNASSIGNED
To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias.
Objectives
UNASSIGNED
To compare demographic data and clinical features in patients with adult-onset acquired and idiopathic dystonias.
Methods
UNASSIGNED
Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult-onset dystonia. Study population included 116 patients with adult-onset acquired dystonia and 651 patients with isolated adult-onset idiopathic dystonia.
Results
UNASSIGNED
Comparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor.
Conclusions
UNASSIGNED
The clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.
Identifiants
pubmed: 37476305
doi: 10.1002/mdc3.13801
pii: MDC313801
pmc: PMC10354612
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1107-1113Informations de copyright
© 2023 International Parkinson and Movement Disorder Society.
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