Insight into contact force local impedance technology for predicting effective pulmonary vein isolation.

Background

Highly localized impedance (LI) measurements during atrial fibrillation (AF) ablation have the potential to act as a reliable predictor of the durability of the lesions created.

Objective

We aimed to collect data on the procedural parameters affecting LI-guided ablation in a large multicenter registry.

Methods

A total of 212 consecutive patients enrolled in the CHARISMA registry and undergoing their first pulmonary vein (PV) isolation for paroxysmal and persistent AF were included.

Results

In all, 13,891 radiofrequency (RF) applications of ≥3 s duration were assessed. The first-pass PV isolation rate was 93.3%. A total of 80 PV gaps were detected. At successful ablation spots, baseline LI and absolute LI drop were larger than at PV gap spots (161.4 ± 19 Ω vs. 153.0 ± 13 Ω,

Conclusion

An LI drop >21 Ω at anterior sites and >18 Ω at posterior sites predicts successful ablation. A higher CF was associated with an increased likelihood of ideal LI drop. The combination of good CF and adequate LI drop allows a significant reduction in RF DT.

Clinical trial registration

http://clinicaltrials.gov/, identifier: NCT03793998.

Informations de copyright

© 2023 Lepillier, Maggio, De Sanctis, Malacrida, Stabile, Zakine, Champ-Rigot, Anselmino, Segreti, Dell'Era, Garnier, Mascia, Pandozi, Dello Russo, Scaglione, Cosaro, Ferraro, Paziaud, Maglia and Solimene.

Déclaration de conflit d'intérêts

MM and GC are employees of Boston Scientific. MA is a consultant for Boston Scientific and Biosense Webster and a clinical proctor for Medtronic, and has received educational fees from Abbott. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor TS declared a past co-authorship with the author FS.