Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Ca2+ channel
active zone
cochlea
hearing
synaptic vesicle
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
06 09 2023
06 09 2023
Historique:
revised:
30
06
2023
received:
20
12
2022
accepted:
06
07
2023
pmc-release:
21
07
2024
medline:
7
9
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essential for sound encoding and is attributed to a distinct molecular machinery with unique players or splice variants compared to conventional neuronal synapses. Among these is the active zone (AZ) scaffold protein piccolo/aczonin, which is represented by its short splice variant piccolino at cochlear and retinal ribbon synapses. While the function of piccolo at synapses of the central nervous system has been intensively investigated, the role of piccolino at IHC synapses remains unclear. In this study, we characterize the structure and function of IHC synapses in piccolo gene-trap mutant rats (Pclo
Identifiants
pubmed: 37477166
doi: 10.15252/embr.202256702
pmc: PMC10481675
doi:
Substances chimiques
Pclo protein, rat
0
Cytoskeletal Proteins
0
Neuropeptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e56702Subventions
Organisme : NIH HHS
ID : R24 OD011108
Pays : United States
Informations de copyright
© 2023 The Authors.
Références
Physiol Rev. 2018 Oct 1;98(4):2063-2096
pubmed: 30067155
Aging (Albany NY). 2021 Apr 21;13(8):11678-11695
pubmed: 33882456
J Biol Chem. 2003 May 30;278(22):20268-77
pubmed: 12654920
Neuron. 2014 Sep 17;83(6):1389-403
pubmed: 25199706
EMBO J. 2015 Nov 3;34(21):2686-702
pubmed: 26446278
Hear Res. 1990 May;45(3):191-202
pubmed: 2358413
Int J Mol Sci. 2019 Apr 30;20(9):
pubmed: 31052288
Neuron. 2003 Mar 6;37(5):775-86
pubmed: 12628168
Elife. 2018 Jan 12;7:
pubmed: 29328021
J Neurosci. 2005 Dec 14;25(50):11577-85
pubmed: 16354915
Nat Neurosci. 2002 Feb;5(2):147-54
pubmed: 11802170
Hear Res. 1980 Jul;3(1):45-63
pubmed: 7400048
Nat Commun. 2018 Jan 18;9(1):290
pubmed: 29348575
Front Synaptic Neurosci. 2016 Jan 12;7:19
pubmed: 26793095
J Cell Biol. 2008 Jun 2;181(5):831-46
pubmed: 18519737
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16341-6
pubmed: 17911259
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6504-9
pubmed: 20332206
Eur J Neurosci. 2001 Sep;14(6):977-86
pubmed: 11595036
Pflugers Arch. 1988 Feb;411(2):137-46
pubmed: 3357753
J Comp Neurol. 2013 Oct 1;521(14):3260-71
pubmed: 23787810
Nat Commun. 2020 Jun 25;11(1):3208
pubmed: 32587250
Nat Neurosci. 2009 Apr;12(4):444-53
pubmed: 19270686
Front Synaptic Neurosci. 2017 Oct 25;9:14
pubmed: 29118709
EMBO J. 2013 Apr 3;32(7):954-69
pubmed: 23403927
EMBO J. 2021 Mar 1;40(5):e106010
pubmed: 33346936
J Assoc Res Otolaryngol. 2014 Aug;15(4):571-83
pubmed: 24825663
J Neurosci. 1982 Jul;2(7):942-57
pubmed: 7097321
J Neurosci. 2019 Apr 3;39(14):2606-2619
pubmed: 30696732
Neuron. 2002 Nov 14;36(4):649-59
pubmed: 12441054
J Neurocytol. 1986 Dec;15(6):693-714
pubmed: 3819777
J Physiol. 2021 May;599(10):2527-2557
pubmed: 33644871
Cell. 2018 Aug 23;174(5):1229-1246.e17
pubmed: 30078709
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Nat Neurosci. 2009 Mar;12(3):303-10
pubmed: 19219039
Nat Commun. 2018 Sep 12;9(1):3691
pubmed: 30209249
J Neurosci. 2017 Mar 1;37(9):2471-2484
pubmed: 28154149
Trans Am Otol Soc. 1965;53:35-58
pubmed: 5834666
Nature. 2005 Apr 14;434(7035):889-94
pubmed: 15829963
Neuron. 2003 Mar 6;37(5):787-800
pubmed: 12628169
J Acoust Soc Am. 1974 Dec;56(6):1835-47
pubmed: 4443483
J Cell Biol. 1998 Jul 27;142(2):499-509
pubmed: 9679147
EMBO J. 2019 Mar 1;38(5):
pubmed: 30733243
Elife. 2020 Jan 08;9:
pubmed: 31913118
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3141-9
pubmed: 26034270
Elife. 2019 May 10;8:
pubmed: 31074746
J Neurosci. 2011 Jan 19;31(3):801-8
pubmed: 21248103
EMBO J. 2016 May 17;35(10):1098-114
pubmed: 26929012
Elife. 2021 Oct 07;10:
pubmed: 34617508
J Neurosci. 2019 Jul 3;39(27):5284-5298
pubmed: 31085606
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8
pubmed: 10639174
J Neurophysiol. 2005 Jan;93(1):557-69
pubmed: 15456804
J Comp Neurol. 2001 Oct 15;439(2):224-34
pubmed: 11596050
EMBO J. 2014 Feb 3;33(3):247-64
pubmed: 24442635
J Physiol. 2018 Apr 15;596(8):1485-1499
pubmed: 29194628
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1028-37
pubmed: 25691754
J Neurosci. 2013 Mar 6;33(10):4456-67
pubmed: 23467361
Cell Rep. 2021 Jan 5;34(1):108551
pubmed: 33406431
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6415-6424
pubmed: 30867284
PLoS One. 2013 Aug 06;8(8):e70373
pubmed: 23936420
Neuron. 2010 Nov 18;68(4):724-38
pubmed: 21092861
Elife. 2018 Jan 12;7:
pubmed: 29328020
EMBO J. 2016 Dec 1;35(23):2519-2535
pubmed: 27729456
J Comp Neurol. 1990 Nov 15;301(3):443-60
pubmed: 2262601
J Neurosci. 2010 Jun 2;30(22):7587-97
pubmed: 20519533
J Neurosci. 2015 Sep 23;35(38):13133-47
pubmed: 26400943
Cell Tissue Res. 2015 Jul;361(1):95-114
pubmed: 25874597
Front Cell Neurosci. 2014 Sep 03;8:259
pubmed: 25232303
J Neurophysiol. 2006 Oct;96(4):2025-33
pubmed: 16738212
EMBO Rep. 2023 Sep 6;24(9):e56702
pubmed: 37477166
Nat Rev Neurosci. 2010 Dec;11(12):812-22
pubmed: 21045860
Eur J Cell Biol. 1996 Mar;69(3):214-23
pubmed: 8900486
Elife. 2022 Dec 23;11:
pubmed: 36562477
Hear Res. 2006 Nov;221(1-2):104-18
pubmed: 17005343
Front Cell Neurosci. 2017 Nov 02;11:334
pubmed: 29163046
J Acoust Soc Am. 1978 Feb;63(2):442-55
pubmed: 670542
Neuron. 2000 Dec;28(3):857-72
pubmed: 11163272
Nat Neurosci. 2011 Jul 24;14(9):1135-41
pubmed: 21785435
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4716-25
pubmed: 27462107
J Neurosci. 2011 Nov 16;31(46):16637-50
pubmed: 22090491
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):E392-401
pubmed: 21712437
J Struct Biol. 1996 Jan-Feb;116(1):71-6
pubmed: 8742726
J Cell Biol. 1963 Apr;17:208-12
pubmed: 13986422
Front Syst Neurosci. 2023 Mar 02;17:1100505
pubmed: 36936507
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4483-8
pubmed: 19246382
Front Synaptic Neurosci. 2021 Jun 17;13:678575
pubmed: 34220482
J Microsc. 2018 May;270(2):142-149
pubmed: 29194648
Cell. 2018 Aug 23;174(5):1247-1263.e15
pubmed: 30078710
J Cell Sci. 2020 Jan 22;133(2):
pubmed: 31843760
EMBO Rep. 2018 Nov;19(11):
pubmed: 30201800
Physiol Rev. 2020 Jan 1;100(1):103-144
pubmed: 31373863