The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion.
Ca2+ homeostasis
US21 protein
cell migration
human cytomegalovirus
viroporin
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
medline:
4
9
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus' cell tropism and its evasion of host innate immune responses. US21, one of the 10 US12 genes (US12-US21), is a descendant of a captured cellular transmembrane BAX inhibitor motif-containing gene. It encodes a 7TMD endoplasmic reticulum (ER)-resident viroporin (pUS21) capable of reducing the Ca
Identifiants
pubmed: 37477430
doi: 10.1128/mbio.00749-23
pmc: PMC10470750
doi:
Substances chimiques
Viroporin Proteins
0
Calpain
EC 3.4.22.-
Talin
0
Viral Proteins
0
Calcium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0074923Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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