Facial mimicry is not modulated by dopamine D2/3 and opioid receptor antagonism.
Amisulpride
Dopamine
Electromyography
Embodiment
Facial mimicry
Naltrexone
Opioid
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
23
04
2023
accepted:
13
07
2023
medline:
19
9
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
According to theories of embodied cognition, facial mimicry - the spontaneous, low-intensity imitation of a perceived emotional facial expression - is first an automatic motor response, whose accompanying proprioceptive feedback contributes to emotion recognition. Alternative theoretical accounts, however, view facial mimicry as an emotional response to a rewarding stimulus, and/or an affiliative signal, and thus reject the view of an automatic motor copy. To contribute to this debate and further investigate the neural basis of facial mimicry, as well as its relation to reward processing, we measured facial reactions to dynamic happy and angry faces after pharmacologically manipulating the opioid and dopamine systems - respectively, thought to subserve 'liking' and 'wanting' of rewards. In a placebo-controlled, double-blind experiment, 130 volunteers received in a between-subjects design 50 mg of the opioidergic antagonist naltrexone, 400 mg of the dopaminergic antagonist amisulpride, or placebo. Clear occurrence of facial mimicry, measured 4 h after drug intake with electromyography (EMG) of the zygomaticus major and corrugator supercilii muscles, was found. However, facial mimicry was not affected by either compound, as shown with both frequentist statistics, and a Bayesian asymptotic regression model. This null finding does not support the hypothesis that facial mimicry (of happiness) reflects an emotional response to a rewarding stimulus, leaving open the possibility of facial mimicry being an automatic motor copy. The results are relevant to the discussion about the psychological nature and the neural basis of facial mimicry, although they should be considered preliminary, given the challenges of interpreting null findings when targeting a novel effect of unknown size.
Identifiants
pubmed: 37477676
doi: 10.1007/s00213-023-06426-3
pii: 10.1007/s00213-023-06426-3
pmc: PMC10506945
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Narcotic Antagonists
0
Receptors, Opioid
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2081-2091Informations de copyright
© 2023. The Author(s).
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