Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
21 07 2023
21 07 2023
Historique:
medline:
23
10
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition of the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis. Consistently, the adrenocortical mitochondria of
Identifiants
pubmed: 37478183
doi: 10.1126/sciadv.adf6710
pmc: PMC10361602
doi:
Substances chimiques
Fatty Acid Desaturases
EC 1.14.19.-
Fatty Acids, Unsaturated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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