The gut mucus network: A dynamic liaison between microbes and the immune system.
Colon
Inflammatory bowel disease
Microbiota
Mucin-type O-glycans
Mucus
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
08
10
2022
revised:
24
06
2023
accepted:
08
07
2023
medline:
21
8
2023
pubmed:
22
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
A complex mucus network made up of large polymers of the mucin-family glycoprotein MUC2 exists between the large intestinal microbial mass and epithelial and immune cells. This has long been understood as an innate immune defense barrier against the microbiota and other luminal threats that reinforces the barrier function of the epithelium and limits microbiota contact with the tissues. However, past and recent studies have provided new evidence of how critical the mucus network is to act as a 'liaison' between host and microbe to mediate anti-inflammatory, mutualistic interactions with the microbiota and protection from pathogens. This review summarizes historical and recent insights into the formation of the gut mucus network, how the microbes and immune system influence mucus, and in turn, how the mucus influences immune responses to the microbiota.
Identifiants
pubmed: 37478802
pii: S1044-5323(23)00098-2
doi: 10.1016/j.smim.2023.101807
pii:
doi:
Substances chimiques
Mucin-2
0
Mucins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101807Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.