Representations in human primary visual cortex drift over time.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 07 2023
21 07 2023
Historique:
received:
13
11
2022
accepted:
13
07
2023
medline:
26
7
2023
pubmed:
22
7
2023
entrez:
21
7
2023
Statut:
epublish
Résumé
Primary sensory regions are believed to instantiate stable neural representations, yet a number of recent rodent studies suggest instead that representations drift over time. To test whether sensory representations are stable in human visual cortex, we analyzed a large longitudinal dataset of fMRI responses to images of natural scenes. We fit the fMRI responses using an image-computable encoding model and tested how well the model generalized across sessions. We found systematic changes in model fits that exhibited cumulative drift over many months. Convergent analyses pinpoint changes in neural responsivity as the source of the drift, while population-level representational dissimilarities between visual stimuli were unchanged. These observations suggest that downstream cortical areas may read-out a stable representation, even as representations within V1 exhibit drift.
Identifiants
pubmed: 37479723
doi: 10.1038/s41467-023-40144-w
pii: 10.1038/s41467-023-40144-w
pmc: PMC10361968
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4422Subventions
Organisme : Intramural NIH HHS
ID : ZIA MH002966
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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