Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets?

Animals Piperonyl Butoxide / pharmacology Mosquito Control Anopheles Insecticide-Treated Bednets Mosquito Vectors Pyrethrins / pharmacology Insecticides / pharmacology Insecticide Resistance
Anopheles gambiae Antagonism Chlorfenapyr Experimental huts Insecticide-treated nets Malaria Mosquitoes Piperonyl butoxide Pro-insecticide Pyrethroid Vector control

Journal

Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802

Informations de publication

Date de publication:
21 Jul 2023
Historique:
received: 30 03 2023
accepted: 14 07 2023
medline: 23 10 2023
pubmed: 22 7 2023
entrez: 21 7 2023
Statut: epublish

Résumé

Pyrethroid-chlorfenapyr (CFP) and pyrethroid-piperonyl butoxide (PBO) nets are being scaled across endemic countries to improve control of malaria transmitted by pyrethroid-resistant mosquitoes. CFP is a pro-insecticide requiring activation by mosquito cytochrome P450 monooxygenase enzymes (P450s) while PBO improves pyrethroid potency by inhibiting the action of these enzymes in pyrethroid-resistant mosquitoes. The inhibitory action of PBO against P450s may thus reduce the efficacy of pyrethroid-CFP nets when applied inside the same household as pyrethroid-PBO nets. Two experimental hut trials were performed to evaluate the entomological impact of two different types of pyrethroid-CFP ITN (Interceptor The vector population was susceptible to CFP but exhibited a high intensity of pyrethroid resistance that was overcame by PBO pre-exposure. Vector mortality was significantly lower in huts with combinations of pyrethroid-CFP nets plus pyrethroid-PBO nets compared to huts with two pyrethroid-CFP nets (74% vs. 85% for Interceptor This study shows evidence of a reduced performance of pyrethroid-CFP nets when combined with pyrethroid-PBO ITNs compared to when applied alone and higher efficacy with net combinations that included pyrethroid-CFP nets. These findings suggest that in similar contexts, prioritizing distribution of pyrethroid-CFP nets over other net types would maximize vector control impact.

Sections du résumé

BACKGROUND BACKGROUND
Pyrethroid-chlorfenapyr (CFP) and pyrethroid-piperonyl butoxide (PBO) nets are being scaled across endemic countries to improve control of malaria transmitted by pyrethroid-resistant mosquitoes. CFP is a pro-insecticide requiring activation by mosquito cytochrome P450 monooxygenase enzymes (P450s) while PBO improves pyrethroid potency by inhibiting the action of these enzymes in pyrethroid-resistant mosquitoes. The inhibitory action of PBO against P450s may thus reduce the efficacy of pyrethroid-CFP nets when applied inside the same household as pyrethroid-PBO nets.
METHODS METHODS
Two experimental hut trials were performed to evaluate the entomological impact of two different types of pyrethroid-CFP ITN (Interceptor
RESULTS RESULTS
The vector population was susceptible to CFP but exhibited a high intensity of pyrethroid resistance that was overcame by PBO pre-exposure. Vector mortality was significantly lower in huts with combinations of pyrethroid-CFP nets plus pyrethroid-PBO nets compared to huts with two pyrethroid-CFP nets (74% vs. 85% for Interceptor
CONCLUSIONS CONCLUSIONS
This study shows evidence of a reduced performance of pyrethroid-CFP nets when combined with pyrethroid-PBO ITNs compared to when applied alone and higher efficacy with net combinations that included pyrethroid-CFP nets. These findings suggest that in similar contexts, prioritizing distribution of pyrethroid-CFP nets over other net types would maximize vector control impact.

Identifiants

DOI: 10.1186/s12936-023-04648-6 PMID: 37480030 PMC: PMC10362717
pubmed: 37480030
doi: 10.1186/s12936-023-04648-6
pii: 10.1186/s12936-023-04648-6
pmc: PMC10362717
doi:

Substances chimiques

chlorfenapyr NWI20P05EB
milbemycin oxime 0502PUN0GT
Piperonyl Butoxide LWK91TU9AH
Pyrethrins 0
Insecticides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

214

Informations de copyright

© 2023. The Author(s).

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Auteurs

Thomas Syme (T)

London School of Hygiene & Tropical Medicine, London, UK. Thomas.syme@lshtm.ac.uk.
Centre de Recherche Entomologique de Cotonou, Cotonou, Benin. Thomas.syme@lshtm.ac.uk.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin. Thomas.syme@lshtm.ac.uk.

Judicaël Nounagnon (J)

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin.

Boris N'dombidjé (B)

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin.

Martial Gbegbo (M)

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin.

Abel Agbevo (A)

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin.

Juniace Ahoga (J)

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin.

Corine Ngufor (C)

London School of Hygiene & Tropical Medicine, London, UK. corine.ngufor@lshtm.ac.uk.
Centre de Recherche Entomologique de Cotonou, Cotonou, Benin. corine.ngufor@lshtm.ac.uk.
Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin. corine.ngufor@lshtm.ac.uk.

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Classifications MeSH

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