Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy.

Mice Animals Immune Checkpoint Inhibitors B7-H1 Antigen Biotin Immunotherapy / methods Resorcinols Cell Line, Tumor Neoplasms

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 08 2023
Historique:
medline: 11 8 2023
pubmed: 22 7 2023
entrez: 21 7 2023
Statut: ppublish

Résumé

In this work, we rationally designed, synthesized, and evaluated a series of novel d-(+)-biotin-conjugated PD-L1 inhibitors for targeted cancer therapy. Among them,

Identifiants

DOI: 10.1021/acs.jmedchem.3c00479 PMID: 37480153
pubmed: 37480153
doi: 10.1021/acs.jmedchem.3c00479
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0
B7-H1 Antigen 0
dibenzyl ether 2O6CNO27RJ
Biotin 6SO6U10H04
Resorcinols 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10364-10380

Auteurs

Zongbao Ding (Z)

Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, P. R. China.

Shuanghu Wang (S)

The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang 323000, China.

Yaru Shi (Y)

The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang 323000, China.

Xiaoting Fei (X)

School of Medicine, Hubei Polytechnic University, Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi 435003, China.

Binbin Cheng (B)

School of Medicine, Hubei Polytechnic University, Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi 435003, China.

Yiyu Lu (Y)

Oncology Department, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan 528200, China.

Jianjun Chen (J)

School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China.
ORCID: 0000-0001-5668-6572

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Biotine › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Résorcinol › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Discovery of Novel d-(+)-Biotin-Conjugated...
questionsmedicales.fr › Tumeurs › Discovery of Novel d-(+)-Biotin-Conjugated...