Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer's Disease Brain Pathology Exacerbated by Sleep Deprivation.

Humans Alzheimer Disease / drug therapy Amyloid beta-Peptides / immunology Antibodies, Monoclonal Brain Neuroprotection Sleep Deprivation Tumor Necrosis Factor-alpha / immunology Nanoparticle Drug Delivery System / chemistry tau Proteins / immunology
Alzheimer’s disease Brain pathology Monoclonal antibodies Nanomedicine amyloid beta peptide Nanowired delivery Neuroprotection Phosphorylated p-tau Serotonin6 receptor antagonist Sleep deprivation

Journal

Advances in neurobiology
ISSN: 2190-5215
Titre abrégé: Adv Neurobiol
Pays: United States
ID NLM: 101571545

Informations de publication

Date de publication:
2023
Historique:
medline: 24 7 2023
pubmed: 22 7 2023
entrez: 22 7 2023
Statut: ppublish

Résumé

Sleep deprivation induces amyloid beta peptide and phosphorylated tau deposits in the brain and cerebrospinal fluid together with altered serotonin metabolism. Thus, it is likely that sleep deprivation is one of the predisposing factors in precipitating Alzheimer's disease (AD) brain pathology. Our previous studies indicate significant brain pathology following sleep deprivation or AD. Keeping these views in consideration in this review, nanodelivery of monoclonal antibodies to amyloid beta peptide (AβP), phosphorylated tau (p-tau), and tumor necrosis factor alpha (TNF-α) in sleep deprivation-induced AD is discussed based on our own investigations. Our results suggest that nanowired delivery of monoclonal antibodies to AβP with p-tau and TNF-α induces superior neuroprotection in AD caused by sleep deprivation, not reported earlier.

Identifiants

DOI: 10.1007/978-3-031-32997-5_1 PMID: 37480458
pubmed: 37480458
doi: 10.1007/978-3-031-32997-5_1
doi:

Substances chimiques

Amyloid beta-Peptides 0
Antibodies, Monoclonal 0
cerebrolysin 37KZM6S21G
Tumor Necrosis Factor-alpha 0
Nanoparticle Drug Delivery System 0
tau Proteins 0

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3-53

Informations de copyright

© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Aruna Sharma (A)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Lianyuan Feng (L)

Department of Neurology, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.

Dafin F Muresanu (DF)

Department Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania.
"RoNeuro" Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.

Z Ryan Tian (ZR)

Department Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA.

José Vicente Lafuente (JV)

LaNCE, Department Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.

Anca D Buzoianu (AD)

Department of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Ala Nozari (A)

Anesthesiology & Intensive Care, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.

Igor Bryukhovetskiy (I)

Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.

Igor Manzhulo (I)

Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.

Lars Wiklund (L)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Hari Shanker Sharma (HS)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Sharma@surgsci.uu.se.

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