LMO2 attenuates glycolytic metabolism and facilitates cytotoxic T-lymphocyte infiltration in the tumor environment of lung and breast cancers.
Glycolysis
LMO2
Lactic acid
Tumor-infiltrating T Cells
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
received:
10
07
2023
accepted:
13
07
2023
medline:
21
8
2023
pubmed:
23
7
2023
entrez:
22
7
2023
Statut:
ppublish
Résumé
Aerobic glycolysis preferentially exists in many cancer cells. LMO2 is an adaptor protein ubiquitously expressed in many epithelia and their malignancies, and it mediates broad-spectrum protein interactions. In this study, results showed that LMO2 directly interacted with glycolytic enzymes PGK1, PGAM1 and LDHA/LDHB, attenuated the glycolytic metabolism flow characterized by decreased glucose intake, ATP production and lactic acid excretion in lung and breast cancer cells, and was positively associated with of CD8
Identifiants
pubmed: 37480698
pii: S0006-291X(23)00881-1
doi: 10.1016/j.bbrc.2023.07.024
pii:
doi:
Substances chimiques
LMO2 protein, human
0
Proto-Oncogene Proteins
0
Adaptor Proteins, Signal Transducing
0
LIM Domain Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-176Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest There is no conflict of interest in this study.