Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation.

Humans Mice Animals Aging, Premature / genetics Proto-Oncogene Proteins c-myc / genetics Incidence Neoplasms / pathology Aging
CP: Cancer aging

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
29 08 2023
Historique:
received: 08 02 2023
revised: 18 05 2023
accepted: 03 07 2023
medline: 4 9 2023
pubmed: 23 7 2023
entrez: 23 7 2023
Statut: ppublish

Résumé

MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in ways that support tumor induction and maintenance. Although Myc

Identifiants

DOI: 10.1016/j.celrep.2023.112830 PMID: 37481724 PMC: PMC10591215
pubmed: 37481724
pii: S2211-1247(23)00841-0
doi: 10.1016/j.celrep.2023.112830
pmc: PMC10591215
mid: NIHMS1928229
pii:
doi:

Substances chimiques

Proto-Oncogene Proteins c-myc 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

112830

Subventions

Organisme : NCI NIH HHS
ID : P50 CA210964
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174713
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109907
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

Cell. 2005 Feb 25;120(4):483-95
pubmed: 15734681
Mol Cancer Res. 2007 Nov;5(11):1181-9
pubmed: 17982115
Cold Spring Harb Perspect Biol. 2012 Dec 01;4(12):
pubmed: 23209155
Pathobiol Aging Age Relat Dis. 2011;1:
pubmed: 22953032
Cell Cycle. 2011 May 15;10(10):1528-32
pubmed: 21471732
Trends Ecol Evol. 2012 Dec;27(12):698-704
pubmed: 22975220
Oncogene. 2008 Mar 20;27(13):1905-15
pubmed: 17906696
Obesity (Silver Spring). 2010 Sep;18(9):1695-700
pubmed: 20111019
J Physiol. 1995 Jan 15;482 ( Pt 2):449-54
pubmed: 7714835
Oncogene. 1999 May 13;18(19):3004-16
pubmed: 10378696
J Intern Med. 2008 Feb;263(2):167-78
pubmed: 18226094
Breast Cancer Res Treat. 2021 Apr;186(2):273-283
pubmed: 33475878
Pflugers Arch. 2020 Sep;472(9):1273-1298
pubmed: 32591906
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Aging Cell. 2010 Oct;9(5):667-84
pubmed: 20701600
Nature. 2007 Feb 8;445(7128):661-5
pubmed: 17251932
Eur J Clin Nutr. 2019 Feb;73(2):172-178
pubmed: 30283153
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Curr Protoc Mouse Biol. 2015 Dec 02;5(4):283-290
pubmed: 26629772
J Biol Chem. 2000 Jul 21;275(29):21797-800
pubmed: 10823814
Cell. 2010 Apr 30;141(3):432-45
pubmed: 20434984
Cells. 2022 Feb 21;11(4):
pubmed: 35203395
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
J Intern Med. 2021 Jul;290(1):190-202
pubmed: 33453124
Bioinformatics. 2009 Jun 1;25(11):1463-5
pubmed: 19346324
Circ Res. 2018 Sep 14;123(7):905-924
pubmed: 30355076
Nature. 2008 Oct 2;455(7213):679-83
pubmed: 18716624
Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S121-5
pubmed: 11041083
Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E108-16
pubmed: 19887594
J Biol Chem. 2016 Dec 16;291(51):26241-26251
pubmed: 27738108
PLoS One. 2015 Jul 31;10(7):e0134049
pubmed: 26230505
Nature. 2021 Apr;592(7856):695-703
pubmed: 33911272
J Biol Chem. 2017 Jun 16;292(24):10068-10086
pubmed: 28432125
Mech Ageing Dev. 2016 Dec;160:93-116
pubmed: 27530773
Nature. 2017 Dec 7;552(7683):116-120
pubmed: 29186113
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Oncotarget. 2016 May 24;7(21):30379-95
pubmed: 27105497
Genes Dev. 1993 Apr;7(4):671-82
pubmed: 8458579
Oncogene. 2008 Nov 6;27(52):6623-34
pubmed: 18679422
Genes (Basel). 2017 May 25;8(6):
pubmed: 28587062
Front Cell Dev Biol. 2017 Apr 11;5:35
pubmed: 28443280
Cell Mol Gastroenterol Hepatol. 2021;12(1):199-228
pubmed: 33618031
Front Endocrinol (Lausanne). 2020 Jan 14;10:861
pubmed: 31993018
Am J Prev Med. 2014 Mar;46(3 Suppl 1):S7-15
pubmed: 24512933
J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B239-46
pubmed: 12023260
Annu Rev Physiol. 2016;78:23-44
pubmed: 26474213
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
Eur J Pediatr. 1994;153(7 Suppl 1):S62-7
pubmed: 7957389
Ageing Res Rev. 2017 Jan;33:52-66
pubmed: 27215853
Aging (Albany NY). 2019 Apr 26;11(8):2512-2540
pubmed: 31026227
Genome Dyn. 2006;1:218-242
pubmed: 18724063
Nat Biotechnol. 2020 Mar;38(3):276-278
pubmed: 32055031
Am J Phys Anthropol. 1999 Jun;109(2):269-73
pubmed: 10378464
Nucleic Acids Res. 2019 Jul 2;47(W1):W212-W224
pubmed: 31114921
Curr Protoc Mol Biol. 2005 May;Chapter 28:Unit 28.1
pubmed: 18265366
Semin Liver Dis. 2001;21(1):57-69
pubmed: 11296697
Mech Ageing Dev. 2017 Dec;168:30-36
pubmed: 28414025
Pediatr Clin North Am. 2018 Apr;65(2):317-335
pubmed: 29502916
Cell Metab. 2018 Oct 2;28(4):656-666.e1
pubmed: 30017358
Diabetes. 2019 Oct;68(10):1934-1949
pubmed: 31292135
Mol Cell Biol. 2005 Jul;25(14):6225-34
pubmed: 15988031
Cancer Res. 2016 Jun 15;76(12):3463-72
pubmed: 27197165
PLoS One. 2019 Feb 22;14(2):e0212850
pubmed: 30794691
Sci Rep. 2019 Jul 18;9(1):10425
pubmed: 31320689
Cell Metab. 2017 Jan 10;25(1):57-71
pubmed: 28094012
J Clin Invest. 2018 Aug 31;128(9):3662-3670
pubmed: 30059016
Mol Cell Biol. 2005 Sep;25(17):7868-78
pubmed: 16107730
Mol Cell. 2018 Dec 6;72(5):836-848.e7
pubmed: 30415952
Cell Rep. 2018 Apr 3;23(1):213-226.e3
pubmed: 29617661
Cancer Cell. 2019 Nov 11;36(5):483-497.e15
pubmed: 31679823
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Mech Ageing Dev. 2016 Dec;160:41-53
pubmed: 27717883
BMC Cancer. 2018 Jan 22;18(1):87
pubmed: 29357823
Nature. 2020 Jul;583(7817):590-595
pubmed: 32669714
Mol Cell. 2002 May;9(5):1031-44
pubmed: 12049739
Nat Rev Genet. 2005 Aug;6(8):611-22
pubmed: 16136653
Cell Metab. 2020 Mar 3;31(3):549-563.e7
pubmed: 32084377
Biochem Soc Symp. 2006;(73):141-54
pubmed: 16626295
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10258-63
pubmed: 23733953
Interdiscip Top Gerontol Geriatr. 2015;41:15-25
pubmed: 26301976
J Cutan Pathol. 2019 Jul;46(7):508-519
pubmed: 30932205
Nature. 2001 Dec 13;414(6865):768-73
pubmed: 11742404
Cell Growth Differ. 1997 Oct;8(10):1039-48
pubmed: 9342182
Curr Protoc. 2021 Mar;1(3):e90
pubmed: 33780170
J Clin Invest. 2013 Mar;123(3):951-7
pubmed: 23454757
Mol Cell Biol. 2006 Nov;26(22):8418-26
pubmed: 16954380
Cold Spring Harb Symp Quant Biol. 2011;76:369-74
pubmed: 21960526
Semin Cell Dev Biol. 2001 Dec;12(6):449-57
pubmed: 11735379
Curr Top Microbiol Immunol. 2006;302:255-78
pubmed: 16620032
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Aging Cell. 2017 Oct;16(5):918-933
pubmed: 28703423
Cold Spring Harb Perspect Med. 2014 Jun 02;4(6):
pubmed: 24890832
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Cells. 2021 Mar 30;10(4):
pubmed: 33808495
Cancer Res. 2017 Nov 1;77(21):5795-5807
pubmed: 28883002
Genes Dev. 2002 Oct 1;16(19):2530-43
pubmed: 12368264
Genes Cancer. 2010 Jun;1(6):580-6
pubmed: 21779459
PLoS One. 2014 May 23;9(5):e97285
pubmed: 24859015
Nature. 2004 Oct 28;431(7012):1112-7
pubmed: 15475948
J Cell Biol. 2007 Aug 13;178(4):635-48
pubmed: 17698607
J Clin Oncol. 2018 Jul 20;36(21):2206-2215
pubmed: 29874132
Cell. 2012 Mar 30;149(1):22-35
pubmed: 22464321
Cell. 2015 Jan 29;160(3):477-88
pubmed: 25619689
Aging (Albany NY). 2018 Dec 18;10(12):4269-4288
pubmed: 30562164
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5618-23
pubmed: 15800038
Endocrinology. 2018 Nov 1;159(11):3801-3812
pubmed: 30215698
Elife. 2021 Apr 13;10:
pubmed: 33847263
Cells. 2022 Dec 08;11(24):
pubmed: 36552737
Oncotarget. 2015 Jun 30;6(18):15857-70
pubmed: 26036281
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Cold Spring Harb Perspect Biol. 2019 Jan 2;11(1):
pubmed: 30602541
Diabetes. 2012 Aug;61(8):2074-83
pubmed: 22586586
Semin Cancer Biol. 2006 Aug;16(4):253-64
pubmed: 16904903
Eur J Dermatol. 2012 Jul-Aug;22(4):443-55
pubmed: 22436139
Oncotarget. 2015 Oct 20;6(32):32380-95
pubmed: 26474287
Curr Opin Genet Dev. 2010 Feb;20(1):91-5
pubmed: 19962879
Genes Cancer. 2010 Jun;1(6):650-659
pubmed: 21132100
Genes Cancer. 2010 Jun;1(6):555-9
pubmed: 21779458
J Biol Chem. 2019 Nov 15;294(46):17524-17542
pubmed: 31597698
J Biol Chem. 2015 Aug 14;290(33):20100
pubmed: 26276854
Genes (Basel). 2017 Dec 19;8(12):
pubmed: 29257072
Exp Toxicol Pathol. 2006 Jul;57(5-6):377-81
pubmed: 16713211
Nat Rev Mol Cell Biol. 2020 Jul;21(7):384-397
pubmed: 32242127
Cancer Res. 2010 Feb 1;70(3):859-62
pubmed: 20086171
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
PLoS One. 2012;7(5):e37699
pubmed: 22629444
Int J Mol Sci. 2020 Apr 11;21(8):
pubmed: 32290431
Cell Cycle. 2007 May 2;6(9):1024-9
pubmed: 17426456
Bio Protoc. 2017 Apr 20;7(8):
pubmed: 28713848
Sci Rep. 2011;1:134
pubmed: 22355651
Cell Mol Gastroenterol Hepatol. 2022;13(6):1785-1804
pubmed: 35259493
Anal Quant Cytol Histol. 2001 Aug;23(4):291-9
pubmed: 11531144
Annu Rev Med. 2005;56:495-508
pubmed: 15660524
Diabetes Care. 2020 Sep;43(9):2313-2322
pubmed: 32910779
Vet Pathol. 2016 Mar;53(2):233-43
pubmed: 26508696
Cells. 2022 Dec 16;11(24):
pubmed: 36552851
Cell Metab. 2009 Aug;10(2):131-8
pubmed: 19656491
Oncotarget. 2013 Jun;4(6):936-47
pubmed: 23801058
J Nutr Sci Vitaminol (Tokyo). 2011;57(2):123-9
pubmed: 21697630
Future Oncol. 2014 Jan;10(1):107-22
pubmed: 24328412
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):621-32
pubmed: 24051346
Science. 2004 Oct 22;306(5696):636-40
pubmed: 15499007
Biochem Biophys Res Commun. 1986 Feb 26;135(1):105-9
pubmed: 3954759
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Parasitol Today. 1997 Mar;13(3):107-11
pubmed: 15275114
World J Gastroenterol. 2014 Oct 21;20(39):14185-204
pubmed: 25339806
Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):76-84
pubmed: 21115533
Exp Cell Res. 2003 Feb 1;283(1):17-21
pubmed: 12565816
J Hematol Oncol. 2019 Sep 6;12(1):93
pubmed: 31492199
Nat Commun. 2020 Jun 5;11(1):2860
pubmed: 32503978
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
J Biol Chem. 2018 Sep 21;293(38):14740-14757
pubmed: 30087120
Aging Cell. 2002 Oct;1(1):10-6
pubmed: 12882348
Hum Genet. 2020 Mar;139(3):357-369
pubmed: 31834493
Development. 2008 Aug;135(14):2455-65
pubmed: 18550708
Sci Transl Med. 2019 Mar 20;11(484):
pubmed: 30894502
Pigment Cell Melanoma Res. 2012 May;25(3):312-25
pubmed: 22420299
Mol Cell Biochem. 1997 Sep;174(1-2):329-33
pubmed: 9309707
Circ Res. 2016 May 13;118(10):1593-611
pubmed: 27174952
Nature. 2022 Dec;612(7938):148-155
pubmed: 36424410
Front Endocrinol (Lausanne). 2018 Apr 12;9:129
pubmed: 29706933

Auteurs

Huabo Wang (H)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Jie Lu (J)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Taylor Stevens (T)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Alexander Roberts (A)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Jordan Mandel (J)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Raghunandan Avula (R)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; The University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

Bingwei Ma (B)

Tongji University School of Medicine, Shanghai, China.

Yijen Wu (Y)

Department of Developmental Biology, The University of Pittsburgh, Pittsburgh, PA, USA.

Jinglin Wang (J)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; Central South University, Xiangya School of Medicine, Changsha, Hunan 410013, P.R. China.

Clinton Van't Land (CV)

Division of Medical Genetics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Toren Finkel (T)

Division of Cardiology, The Department of Internal Medicine and the UPMC Aging Institute, Pittsburgh, PA 15224, USA.

Jerry E Vockley (JE)

Division of Medical Genetics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Merlin Airik (M)

Division of Nephrology, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Rannar Airik (R)

Division of Nephrology, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Radhika Muzumdar (R)

Division of Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Zhenwei Gong (Z)

Division of Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Michel S Torbenson (MS)

Division of Laboratory Medicine and Pathology, The Mayo Clinic, Rochester, MN 55905, USA.

Edward V Prochownik (EV)

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Microbiology and Molecular Genetics, UPMC, Pittsburgh, PA 15261, USA; Hillman Cancer Center of UPMC, Pittsburgh, PA 15232, USA; Pittsburgh Liver Research Center, UPMC, Pittsburgh, PA 15261, USA. Electronic address: procev@chp.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Eucaryotes › Animaux › Premature aging and reduced cancer incidence...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Vieillissement précoce › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines proto-oncogènes c-myc › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Tumeurs › Premature aging and reduced cancer incidence...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Premature aging and reduced cancer incidence...