Crosstalk between TRPV1 and immune regulation in Fuchs endothelial corneal dystrophy.

Humans Fuchs' Endothelial Dystrophy / genetics Endothelium, Corneal / metabolism Hydrogen Peroxide / metabolism Up-Regulation TRPV Cation Channels / genetics
Fuchs endothelial corneal dystrophy Gene therapy Immune landscape Regulatory T cell Transient receptor potential vanilloid 1

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
09 2023
Historique:
received: 17 04 2023
revised: 25 06 2023
accepted: 18 07 2023
medline: 14 8 2023
pubmed: 24 7 2023
entrez: 23 7 2023
Statut: ppublish

Résumé

Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. Our aim was to investigate the role of transient receptor potential vanilloid subtype 1 (TRPV1) and the associated immune regulation contributing to this pathological condition. Significant upregulation of TRPV1 was detected in the H

Identifiants

DOI: 10.1016/j.clim.2023.109701 PMID: 37482117
pubmed: 37482117
pii: S1521-6616(23)00464-3
doi: 10.1016/j.clim.2023.109701
pii:
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V
TRPV1 protein, human 0
TRPV Cation Channels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109701

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest No competing interests is declared.

Auteurs

Yuchen Cai (Y)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.

Jin Chen (J)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.

Hao Sun (H)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.

Tianyi Zhou (T)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.

Xueyao Cai (X)

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: billy112544op@gmail.com.

Yao Fu (Y)

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address: drfuyao@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Crosstalk between TRPV1 and immune regulation...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies héréditaires de l'oeil › Dystrophies héréditaires de la cornée › Dystrophie endothéliale de Fuchs › Crosstalk between TRPV1 and immune regulation...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium de la cornée › Crosstalk between TRPV1 and immune regulation...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Crosstalk between TRPV1 and immune regulation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Crosstalk between TRPV1 and immune regulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Crosstalk between TRPV1 and immune regulation...