Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility,


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
18 Jul 2023
Historique:
received: 05 04 2023
accepted: 13 06 2023
medline: 24 7 2023
pubmed: 24 7 2023
entrez: 24 7 2023
Statut: epublish

Résumé

Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 co-processed excipients (PECE) were synthesized, and their feasibility as solid dispersion carriers (ATV-PECE-SD) for improving the solubility, permeability, and dissolution rate of ATV was explored. Solid dispersions were assessed in terms of particle size and zeta potential, and solubility,

Identifiants

pubmed: 37483203
doi: 10.1021/acsomega.3c02280
pmc: PMC10357539
doi:

Types de publication

Journal Article

Langues

eng

Pagination

25195-25208

Informations de copyright

© 2023 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Darshan R Telange (DR)

Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.

Neha M Bhaktani (NM)

Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur 441002, Maharashtra, India.

Atul T Hemke (AT)

Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur 441002, Maharashtra, India.

Anil M Pethe (AM)

Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.

Surendra S Agrawal (SS)

Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.

Nilesh R Rarokar (NR)

Rashtrasant Tukadoji Maharaj Nagpur University, Department of Pharmaceutical Sciences, Mahatma Jyotiba Fuley Shaik Shanik Parisar, University Campus, Amravati Road, Nagpur 440033, Maharashtra, India.

Shirish P Jain (SP)

Rajarshi Shahu College of Pharmacy, Malvihir, Buldana 443001, Maharashtra, India.

Classifications MeSH