Methylphenidate is more effective to improve inhibitory control and working memory compared to tDCS in children and adolescents with attention deficit/hyperactivity disorder: a proof-of-concept study.
MPH
drug treatments
evidence-based medicine
executive functions
neurodevelopmental disorders
non-invasive brain stimulation
transcranial direct current stimulation
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
02
2023
accepted:
22
06
2023
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is characterized by an inappropriate, pervasive and persistent pattern of inattention, hyperactivity, and/or impulsivity and associated with substantial functional impairment. Despite considerable advances in the understanding and management of ADHD, some patients do not respond well to methylphenidate (MPH), the first-choice pharmacological treatment. Over the past decades, among non-invasive brain stimulation techniques, transcranial direct current stimulation (tDCS) has proven to be an effective and safe technique to improve behavior and cognition in children with neurodevelopmental disorders, including ADHD, by modifying cortical excitability. However, the effect of tDCS has never been directly compared with that of the MPH. The present randomized sham-controlled trial evaluated the effect of a single session of anodal tDCS compared with the administration of a single dose of MPH in children and adolescents with ADHD. After completing baseline assessment (T0), 26 children and adolescents with ADHD were exposed to 3 conditions with a 24-h interval-sessions: (A) a single session of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC); (B) a single session of sham tDCS over the left DLPFC; (C) a single dose of MPH. Our results showed that after administering a single dose of MPH, children and adolescents with ADHD improved inhibitory control and visual-spatial WM compared with baseline, anodal, and sham tDCS. However, a single session of active tDCS over the left DLPFC was not effective compared with either baseline or sham tDCS. In conclusion, our protocol in ADHD involving a single tDCS session did not demonstrate consistent improvements in neurocognitive features compared with baseline, sham tDCS, or single MPH administration. Different protocols need to be developed to further test the effectiveness of tDCS in improving ADHD symptoms.
Identifiants
pubmed: 37483344
doi: 10.3389/fnins.2023.1170090
pmc: PMC10360130
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1170090Informations de copyright
Copyright © 2023 D’Aiello, Lazzaro, Battisti, Pani, Di Vara, De Rossi, Pretelli, Costanzo, Vicari and Menghini.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cerebellum. 2020 Dec;19(6):788-798
pubmed: 32666284
Neuropsychologia. 2011 Apr;49(5):800-804
pubmed: 21335013
J Affect Disord. 2014 Jun;162:43-9
pubmed: 24767004
J Am Acad Child Adolesc Psychiatry. 2004 Mar;43(3):260-8
pubmed: 15076258
Dev Psychopathol. 2005 Summer;17(3):785-806
pubmed: 16262992
Psychol Rev. 2014 Jan;121(1):66-95
pubmed: 24490789
Biol Psychiatry. 2005 Jun 1;57(11):1416-23
pubmed: 15950016
Neuropsychologia. 2009 Jan;47(1):212-7
pubmed: 18725237
J Atten Disord. 2019 Mar;23(5):423-434
pubmed: 27179355
Behav Res Methods. 2019 Feb;51(1):195-203
pubmed: 30734206
Brain Stimul. 2013 May;6(3):424-32
pubmed: 22695026
Front Cell Neurosci. 2016 Mar 22;10:72
pubmed: 27147964
J Atten Disord. 2022 Nov;26(13):1685-1697
pubmed: 35603751
Psychol Med. 2020 Apr;50(6):894-919
pubmed: 32216846
Exp Brain Res. 2014 Oct;232(10):3345-51
pubmed: 24992897
Neuroimage. 2007 Feb 1;34(3):1182-90
pubmed: 17126039
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14259-64
pubmed: 25225387
Noro Psikiyatr Ars. 2019 Mar;56(1):27-31
pubmed: 30911234
Sci Rep. 2020 Mar 12;10(1):4622
pubmed: 32165722
Neuroscience. 2020 Sep 15;444:149-159
pubmed: 32730946
Neurotherapeutics. 2012 Jul;9(3):490-9
pubmed: 22976615
Neuroreport. 2012 Jan 25;23(2):55-60
pubmed: 22146580
J Cogn Neurosci. 2016 Aug;28(8):1063-89
pubmed: 27054400
Int J Neuropsychopharmacol. 2011 Sep;14(8):1133-45
pubmed: 21320389
J Psychiatry Neurosci. 2020 Oct 1;46(1):E14-E33
pubmed: 33009906
Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):475-485
pubmed: 33029947
PLoS One. 2019 Apr 12;14(4):e0215095
pubmed: 30978259
Neurosci Bull. 2020 Oct;36(10):1191-1212
pubmed: 32418073
Neuropsychopharmacology. 2006 Nov;31(11):2376-83
pubmed: 16855530
J Physiol. 2017 Feb 15;595(4):1273-1288
pubmed: 27723104
Neurosci Biobehav Rev. 2021 Sep;128:789-818
pubmed: 33549739
Brain Stimul. 2017 Jan - Feb;10(1):51-58
pubmed: 28104085
Drug Alcohol Depend. 2014 Jul 1;140:78-84
pubmed: 24814566
J Atten Disord. 2020 Nov;24(13):1928-1943
pubmed: 28938852
Prog Brain Res. 2021;264:117-150
pubmed: 34167653
Neuroimage. 2015 Apr 1;109:140-50
pubmed: 25613437
Brain Sci. 2018 May 06;8(5):
pubmed: 29734768
Neurosci Biobehav Rev. 2012 Nov;36(10):2248-56
pubmed: 22922163
Hum Brain Mapp. 2014 Apr;35(4):1261-72
pubmed: 23417778
Neurosci Biobehav Rev. 2018 Feb;85:81-92
pubmed: 28688701
Trends Cogn Sci. 2006 Mar;10(3):117-23
pubmed: 16460990
Front Psychol. 2022 Sep 09;13:986242
pubmed: 36160506
Am J Psychiatry. 2006 Jun;163(6):1052-60
pubmed: 16741206
J Am Acad Child Adolesc Psychiatry. 2022 May;61(5):626-646
pubmed: 34534624
Brain Stimul. 2015 Sep-Oct;8(5):898-905
pubmed: 26279408
Synapse. 2006 Mar 15;59(4):243-51
pubmed: 16385551
Prog Brain Res. 2021;264:191-210
pubmed: 34167656
IBRO Neurosci Rep. 2021 Dec 24;12:55-64
pubmed: 35746969
JAMA Psychiatry. 2016 Aug 1;73(8):815-825
pubmed: 27276220
Neuropsychology. 2015 Nov;29(6):874-81
pubmed: 25938917
Neurosci Biobehav Rev. 2015 Oct;57:46-62
pubmed: 26232699
Exp Clin Psychopharmacol. 2022 Apr;30(2):209-219
pubmed: 33475395
Nucl Med Commun. 2001 Dec;22(12):1333-40
pubmed: 11711904
Eur Child Adolesc Psychiatry. 2004;13 Suppl 1:I7-30
pubmed: 15322953
Biol Psychiatry. 2014 Oct 15;76(8):603-15
pubmed: 24231201
BMC Sports Sci Med Rehabil. 2022 Apr 15;14(1):68
pubmed: 35428346
Neuropharmacology. 2009 Dec;57(7-8):640-52
pubmed: 19715709
Neurosci Biobehav Rev. 2021 Sep;128:749-765
pubmed: 34271027
Int J Environ Res Public Health. 2022 Apr 11;19(8):
pubmed: 35457447
J Consult Clin Psychol. 2017 Jul;85(7):737-750
pubmed: 28504540
Psychol Med. 2014 Mar;44(4):869-80
pubmed: 23663382
J Physiol. 2000 Sep 15;527 Pt 3:633-9
pubmed: 10990547
Neuroreport. 2016 Mar 23;27(5):295-300
pubmed: 26848997
Am J Psychiatry. 2008 Jul;165(7):889-97
pubmed: 18413706
Lancet Psychiatry. 2018 Sep;5(9):727-738
pubmed: 30097390
Neuron. 2010 Apr 29;66(2):198-204
pubmed: 20434997
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
pubmed: 10393989
J Am Acad Child Adolesc Psychiatry. 2010 Apr;49(4):345-55
pubmed: 20410727
Arch Gen Psychiatry. 1983 Nov;40(11):1228-31
pubmed: 6639293
Clin Neurophysiol. 2021 Mar;132(3):699-707
pubmed: 33561725
Brain Stimul. 2018 Jan - Feb;11(1):52-58
pubmed: 29066167
Clin Neurophysiol. 2020 May;131(5):1146-1154
pubmed: 32029377
Neuropsychol Rehabil. 2011 Oct;21(5):553-9
pubmed: 22011015
Brain Stimul. 2016 Jul-Aug;9(4):501-17
pubmed: 27160468
Elife. 2019 Apr 29;8:
pubmed: 31033438
Front Neurosci. 2016 Nov 30;10:550
pubmed: 27965533
J Abnorm Child Psychol. 1998 Aug;26(4):257-68
pubmed: 9700518
J Child Psychol Psychiatry. 2007 Sep;48(9):899-913
pubmed: 17714375
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
J Abnorm Child Psychol. 2009 Aug;37(6):805-16
pubmed: 19291387
J Atten Disord. 2019 Feb;23(4):325-332
pubmed: 26689935
PLoS One. 2013 Sep 27;8(9):e76112
pubmed: 24086698
JAMA. 2002 Oct 9;288(14):1740-8
pubmed: 12365958
Am J Psychiatry. 2012 Oct;169(10):1038-55
pubmed: 22983386
Clin Neurophysiol. 2017 Jan;128(1):56-92
pubmed: 27866120
Neuroimage Clin. 2015 Jul 09;9:1-12
pubmed: 26266096
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:859-62
pubmed: 23366028
Arch Dis Child Educ Pract Ed. 2010 Feb;95(1):24-7
pubmed: 20145015
Nat Rev Dis Primers. 2015 Aug 06;1:15020
pubmed: 27189265
BMC Med. 2021 Dec 17;19(1):319
pubmed: 34915885
Int J Environ Res Public Health. 2022 Jan 31;19(3):
pubmed: 35162663
Pediatrics. 2015 Apr;135(4):e994-1001
pubmed: 25733754
Brain Res. 2021 Feb 15;1753:147227
pubmed: 33385376
Neuropsychopharmacology. 2011 Jul;36(8):1575-86
pubmed: 21451498
Front Psychol. 2020 Jan 10;10:2812
pubmed: 31998168
Hum Brain Mapp. 2022 Oct 15;43(15):4664-4675
pubmed: 35781371
Front Psychol. 2019 Feb 06;10:135
pubmed: 30787895
Brain Stimul. 2016 Mar-Apr;9(2):197-208
pubmed: 26597929
Front Cell Neurosci. 2015 Aug 11;9:307
pubmed: 26321911
Clin Neurophysiol. 2006 Apr;117(4):845-50
pubmed: 16427357
Pediatrics. 2003 Nov;112(5):e404
pubmed: 14595084
Eur Psychiatry. 2013 Aug;28(6):356-61
pubmed: 23182847
Neurotherapeutics. 2012 Jul;9(3):500-8
pubmed: 22930417
Brain Behav. 2022 Sep;12(9):e2724
pubmed: 35938945
Psychiatry Clin Neurosci. 2022 Oct;76(10):512-524
pubmed: 35773784
Psychol Med. 2023 Jan;53(2):497-512
pubmed: 34225830
Brain Res. 2009 Jun 1;1273:114-28
pubmed: 19281801