Advances in attractive therapeutic approach for macrophage activation syndrome in COVID-19.
COVID-19
SARS-CoV-2
cytokine storm syndrome (CSS)s
macrophage activation syndrome (MAS)
therapy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
04
2023
accepted:
12
06
2023
medline:
26
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
Nowadays, people have relaxed their vigilance against COVID-19 due to its declining infection numbers and attenuated virulence. However, COVID-19 still needs to be concern due to its emerging variants, the relaxation of restrictions as well as breakthrough infections. During the period of the COVID-19 infection, the imbalanced and hyper-responsive immune system plays a critical role in its pathogenesis. Macrophage Activation Syndrome (MAS) is a fatal complication of immune system disease, which is caused by the excessive activation and proliferation of macrophages and cytotoxic T cells (CTL). COVID-19-related hyperinflammation shares common clinical features with the above MAS symptoms, such as hypercytokinemia, hyperferritinemia, and coagulopathy. In MAS, immune exhaustion or defective anti-viral responses leads to the inadequate cytolytic capacity of CTL which contributes to prolonged interaction between CTL, APCs and macrophages. It is possible that the same process also occurred in COVID-19 patients, and further led to a cytokine storm confined to the lungs. It is associated with the poor prognosis of severe patients such as multiple organ failure and even death. The main difference of cytokine storm is that in COVID-19 pneumonia is mainly the specific damage of the lung, while in MAS is easy to develop into a systemic. The attractive therapeutic approach to prevent MAS in COVID-19 mainly includes antiviral, antibiotics, convalescent plasma (CP) therapy and hemadsorption, extensive immunosuppressive agents, and cytokine-targeted therapies. Here, we discuss the role of the therapeutic approaches mentioned above in the two diseases. And we found that the treatment effect of the same therapeutic approach is different.
Identifiants
pubmed: 37483597
doi: 10.3389/fimmu.2023.1200289
pmc: PMC10358730
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1200289Informations de copyright
Copyright © 2023 Chen, Zhang, Chen, Dong, Chang and Tang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet Rheumatol. 2020 Oct;2(10):e594-e602
pubmed: 32864628
J Infect. 2022 Jun;84(6):834-872
pubmed: 35301014
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Mar 15;24(3):249-254
pubmed: 35351253
Ann Rheum Dis. 2021 Jan;80(1):88-95
pubmed: 32978237
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Int J Infect Dis. 2022 Sep;122:332-336
pubmed: 35709964
Crit Care Med. 2020 Dec;48(12):e1350-e1355
pubmed: 32833695
Int J Mol Sci. 2021 Nov 26;22(23):
pubmed: 34884590
JAMA Netw Open. 2023 Jan 3;6(1):e2250647
pubmed: 36633846
Lancet Rheumatol. 2020 Dec;2(12):e754-e763
pubmed: 33015645
Arthritis Rheum. 2008 Aug;58(8):2443-52
pubmed: 18668535
AIDS Rev. 2021 Feb 08;23(1):40-47
pubmed: 33556957
Crit Care. 2020 Jun 16;24(1):353
pubmed: 32546188
Cytokine Growth Factor Rev. 2020 Aug;54:51-62
pubmed: 32636055
Infect Dis Ther. 2021 Mar;10(1):347-362
pubmed: 33280066
Front Med (Lausanne). 2022 Aug 15;9:925751
pubmed: 36045925
BMC Pulm Med. 2020 Nov 16;20(1):301
pubmed: 33198751
Lancet Respir Med. 2021 Mar;9(3):295-304
pubmed: 33493450
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Clin Immunol. 2009 Jul;132(1):10-8
pubmed: 19297252
Lancet. 2020 May 16;395(10236):e83
pubmed: 32423585
Mol Med. 2021 May 11;27(1):48
pubmed: 33975537
Blood. 2005 Feb 15;105(4):1648-51
pubmed: 15466922
Int Immunopharmacol. 2022 Oct;111:109075
pubmed: 35905562
Semin Arthritis Rheum. 2022 Aug;55:152043
pubmed: 35696776
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
N Engl J Med. 2022 May 5;386(18):1700-1711
pubmed: 35353960
Eur J Immunol. 2021 Jul;51(7):1615-1627
pubmed: 33930196
Clin Infect Dis. 2023 Jan 6;76(1):165-171
pubmed: 35245942
Cochrane Database Syst Rev. 2020 May 14;5:CD013600
pubmed: 32406927
Nat Med. 2022 Jan;28(1):39-50
pubmed: 35064248
Am J Respir Crit Care Med. 2021 Jan 15;203(2):192-201
pubmed: 33217246
Clin Infect Dis. 2021 Apr 26;72(8):1486-1487
pubmed: 32585016
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Cancer Med. 2020 Nov;9(22):8571-8578
pubmed: 32945149
Emerg Infect Dis. 2020 Sep;26(9):2005-2015
pubmed: 32437316
Reumatol Clin (Engl Ed). 2021 Nov;17(9):556-557
pubmed: 34756322
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Mod Rheumatol Case Rep. 2021 Jul;5(2):360-364
pubmed: 32883165
JAMA Intern Med. 2021 Jan 1;181(1):24-31
pubmed: 33080005
J Rheumatol. 2013 Jun;40(6):761-7
pubmed: 23588947
PLoS Med. 2006 Sep;3(9):e343
pubmed: 16968120
Crit Care. 2020 Apr 2;24(1):128
pubmed: 32241301
BMJ. 2020 Apr 22;369:m1610
pubmed: 32321732
Pathogens. 2021 May 11;10(5):
pubmed: 34064553
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Pharmaceut Med. 2021 Jul;35(4):203-213
pubmed: 34453703
Clin Cardiol. 2020 Oct;43(10):1055-1063
pubmed: 32830894
Lancet Rheumatol. 2020 Aug;2(8):e457-ee458
pubmed: 32835251
Leukemia. 2020 Jul;34(7):1805-1815
pubmed: 32518419
Clin Infect Dis. 2020 Jul 28;71(15):762-768
pubmed: 32161940
EJHaem. 2022 May 11;3(3):1025-1028
pubmed: 35941881
J Crit Care. 2020 Dec;60:328-333
pubmed: 32763058
Pediatr Blood Cancer. 2021 Jul;68(7):e29026
pubmed: 33754483
J Rheumatol. 2021 Feb;48(2):162-164
pubmed: 32482652
Front Immunol. 2022 Jul 06;13:914265
pubmed: 35874753
Pediatrics. 2007 Sep;120(3):e622-8
pubmed: 17698967
Nat Rev Rheumatol. 2021 Mar;17(3):145-157
pubmed: 33547426
Ann Rheum Dis. 2020 Oct;79(10):1381-1382
pubmed: 32376597
JAMA Intern Med. 2020 Sep 1;180(9):1152-1154
pubmed: 32602883
Ann Rheum Dis. 2022 Apr;81(4):e61
pubmed: 32245894
Nature. 2005 Mar 31;434(7033):658-62
pubmed: 15800627
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Exp Ther Med. 2021 Aug;22(2):904
pubmed: 34257717
J Clin Oncol. 2001 May 15;19(10):2665-73
pubmed: 11352958
Int J Mol Sci. 2022 Aug 03;23(15):
pubmed: 35955740
Pulmonology. 2021 Nov-Dec;27(6):486-492
pubmed: 33358260
Br J Clin Pharmacol. 2022 May;88(5):1955-1963
pubmed: 34713921
J Artif Organs. 2021 Sep;24(3):402-406
pubmed: 33459910
J Rheumatol. 2013 Apr;40(4):484-92
pubmed: 23418387
Crit Care. 2020 Aug 4;24(1):481
pubmed: 32753056
EJHaem. 2020 Nov 30;2(1):26-32
pubmed: 33363289
J Med Virol. 2021 Apr;93(4):2090-2098
pubmed: 33038012
Inflamm Regen. 2020 Aug 6;40:19
pubmed: 32834892
Clin Pharmacol Ther. 2020 Feb;107(2):347-358
pubmed: 31449663
Transl Res. 2021 Jun;232:1-12
pubmed: 33684592
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
J Gen Virol. 2013 Aug;94(Pt 8):1749-1760
pubmed: 23620378
BMJ. 2021 Mar 9;372:n579
pubmed: 33687922
Clin Rheumatol. 2018 Dec;37(12):3329-3335
pubmed: 29663156
Case Rep Hematol. 2021 Aug 20;2021:5539126
pubmed: 34462671
Rev Med Virol. 2022 May;32(3):e2295
pubmed: 34558756
J Intern Med. 2021 Feb;289(2):147-161
pubmed: 32696489
Indian J Pharmacol. 2021 May-Jun;53(3):226-228
pubmed: 34169908
Nat Rev Rheumatol. 2016 May;12(5):259-68
pubmed: 27009539
Pediatr Rheumatol Online J. 2020 Jan 10;18(1):2
pubmed: 31924225
J Infect. 2020 Sep;81(3):452-482
pubmed: 32579985
Nat Med. 2021 Oct;27(10):1752-1760
pubmed: 34480127
Blood Purif. 2022;51(5):417-424
pubmed: 34344006
J Mol Biol. 2016 Oct 9;428(20):4154-4167
pubmed: 27515399
J Allergy Clin Immunol. 2023 Jan;151(1):247-259.e7
pubmed: 35973477
Ann Med. 2022 Dec;54(1):516-523
pubmed: 35118917
Mod Rheumatol. 2022 Jan 5;32(1):169-176
pubmed: 33719871
Nat Med. 2021 May;27(5):917-924
pubmed: 33772244
Curr Opin Allergy Clin Immunol. 2022 Dec 1;22(6):364-370
pubmed: 36206094
Int J Hematol. 2022 Dec;116(6):947-955
pubmed: 35948764
N Engl J Med. 2021 Jul 29;385(5):406-415
pubmed: 34133856
Blood Adv. 2022 Jun 14;6(11):3398-3403
pubmed: 35395068
Int J Hematol. 2020 Jul;112(1):122-124
pubmed: 32399895
Intern Emerg Med. 2022 Mar;17(2):431-438
pubmed: 34406633
Eur J Pharmacol. 2022 Jan 5;914:174579
pubmed: 34678244
Int J Infect Dis. 2022 Mar;116:51-58
pubmed: 34971824
Science. 2021 May 21;372(6544):815-821
pubmed: 33853970
N Engl J Med. 2021 Mar 4;384(9):795-807
pubmed: 33306283
Rev Med Virol. 2022 Nov;32(6):e2388
pubmed: 36029180
Front Med (Lausanne). 2021 Jun 04;8:681875
pubmed: 34150813
Cureus. 2022 Jan 19;14(1):e21430
pubmed: 35103223
Blood Purif. 2023;52(2):183-192
pubmed: 36075200
BMJ. 2021 Jan 20;372:n84
pubmed: 33472855
Molecules. 2022 Jul 13;27(14):
pubmed: 35889350
J Clin Med. 2021 Dec 31;11(1):
pubmed: 35011947
Arch Rheumatol. 2022 Jul 22;37(3):435-443
pubmed: 36589607
N Engl J Med. 2020 Dec 10;383(24):2333-2344
pubmed: 33085857
Semin Immunopathol. 2017 Jul;39(5):517-528
pubmed: 28555385
Shock. 2019 Jul;52(1):83-91
pubmed: 30028782
Elife. 2020 Apr 02;9:
pubmed: 32228860
Cytokine. 2021 Jul;143:155544
pubmed: 33926774
Arthritis Rheumatol. 2014 Sep;66(9):2570-9
pubmed: 24839206
Nat Commun. 2021 Aug 11;12(1):4864
pubmed: 34381030
Ir J Med Sci. 2021 Nov;190(4):1637-1638
pubmed: 33433843
N Engl J Med. 2012 Dec 20;367(25):2396-406
pubmed: 23252526
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Expert Opin Investig Drugs. 2021 May;30(5):505-518
pubmed: 33721548
Rheumatol Int. 2022 Mar;42(3):457-467
pubmed: 34515808
Arch Pathol Lab Med. 2022 Apr 1;146(4):507-519
pubmed: 34347856
Int J Infect Dis. 2020 Oct;99:214-218
pubmed: 32585284
Nature. 2021 May;593(7858):270-274
pubmed: 33723411
Crit Care Med. 2022 May 1;50(5):860-872
pubmed: 34605776
Drugs Ther Perspect. 2021;37(12):579-580
pubmed: 34754175
Best Pract Res Clin Rheumatol. 2014 Apr;28(2):277-92
pubmed: 24974063
Clin Immunol. 2020 Sep;218:108517
pubmed: 32585295
Int J Mol Sci. 2020 Jul 06;21(13):
pubmed: 32640747
J Infect. 2020 Jun;80(6):607-613
pubmed: 32283152
Front Pharmacol. 2018 Nov 06;9:1157
pubmed: 30459597
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet Rheumatol. 2022 May;4(5):e351-e361
pubmed: 35368384
Infect Dis Rep. 2022 May 11;14(3):360-371
pubmed: 35645219
Autoimmun Rev. 2020 Jun;19(6):102537
pubmed: 32251717
Blood. 2019 Jun 6;133(23):2465-2477
pubmed: 30992265
Braz J Infect Dis. 2020 Jul - Aug;24(4):365-367
pubmed: 32603679
Front Immunol. 2021 Feb 16;12:614704
pubmed: 33664745
EBioMedicine. 2020 Jul;57:102833
pubmed: 32574956
Ann Geriatr Med Res. 2022 Sep;26(3):208-214
pubmed: 35915954
Gastroenterology. 2021 Mar;160(4):1151-1163.e3
pubmed: 33307029
Front Pediatr. 2022 Jul 28;10:894846
pubmed: 35967555
J Autoimmun. 2020 Jul;111:102452
pubmed: 32291137
Exp Biol Med (Maywood). 2022 Feb;247(4):330-337
pubmed: 35068219
Ann Rheum Dis. 2021 May;80(5):617-625
pubmed: 33277241
Blood Rev. 2021 Mar;46:100743
pubmed: 32829962
Pol Arch Intern Med. 2022 Mar 30;132(3):
pubmed: 35253415
Nature. 2021 Feb;590(7847):635-641
pubmed: 33429418
Eur J Clin Invest. 2021 Nov;51(11):e13663
pubmed: 34375445
Lancet Respir Med. 2020 Dec;8(12):1233-1244
pubmed: 33075298
Int J Infect Dis. 2021 Jan;102:332-334
pubmed: 33157287
Front Immunol. 2019 Feb 01;10:119
pubmed: 30774631
Front Immunol. 2022 Feb 22;13:795315
pubmed: 35340805
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
Med Hypotheses. 2020 Sep;142:109826
pubmed: 32416415
PLoS Pathog. 2011 Oct;7(10):e1002331
pubmed: 22046132
Ther Clin Risk Manag. 2021 Apr 14;17:293-304
pubmed: 33888986
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Mayo Clin Proc. 2021 May;96(5):1262-1275
pubmed: 33958057
Nat Microbiol. 2022 Aug;7(8):1127-1140
pubmed: 35918423
Clin Rheumatol. 2023 Jan;42(1):277-283
pubmed: 36149537
Front Immunol. 2022 Sep 15;13:955523
pubmed: 36189240
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Children (Basel). 2022 May 05;9(5):
pubmed: 35626849
Infez Med. 2021 Dec 10;29(4):495-503
pubmed: 35146357
Int J Antimicrob Agents. 2021 May;57(5):106334
pubmed: 33838224
Crit Care Med. 2022 Dec 1;50(12):1701-1713
pubmed: 36226977
Crit Care. 2020 Aug 8;24(1):492
pubmed: 32771054
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Infect. 2021 Mar;82(3):329-338
pubmed: 33549624
Commun Med (Lond). 2021 Nov 15;1:48
pubmed: 35602219
J Clin Immunol. 2022 May;42(4):901-903
pubmed: 35304666
Nature. 2021 May;593(7858):266-269
pubmed: 33767447
Clin Immunol. 2020 Aug;217:108486
pubmed: 32479985
Am J Respir Crit Care Med. 2018 Mar 15;197(6):757-767
pubmed: 29161116
Indian J Pediatr. 2021 Oct;88(10):1056
pubmed: 34196929
Sci Rep. 2020 Dec 11;10(1):21775
pubmed: 33311551
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Eur Rev Med Pharmacol Sci. 2021 Dec;25(24):8019-8022
pubmed: 34982466
Clin Rheumatol. 2022 Sep;41(9):2817-2823
pubmed: 35590113
Ther Clin Risk Manag. 2018 Jan 24;14:167-171
pubmed: 29416343
Eur J Rheumatol. 2022 Oct;9(4):217-220
pubmed: 35943464
Ann Rheum Dis. 2018 Jun;77(6):840-847
pubmed: 29472362
Respir Physiol Neurobiol. 2020 Sep;280:103492
pubmed: 32659271
Blood Adv. 2023 Feb 28;7(4):533-536
pubmed: 35917457
Lancet Rheumatol. 2020 Jun;2(6):e325-e331
pubmed: 32501454
JAMA. 2021 May 11;325(18):1896-1898
pubmed: 33739374