Effect of Probiotic-Fortified Infant Formula on Infant Gut Health and Microbiota Modulation.
gut health
infant formula
microbiota
probiotics
short-chain fatty acids
Journal
Food science of animal resources
ISSN: 2636-0780
Titre abrégé: Food Sci Anim Resour
Pays: Korea (South)
ID NLM: 101742126
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
11
04
2023
revised:
09
06
2023
accepted:
09
06
2023
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
ppublish
Résumé
Compared to infant formula, breast milk is the best source of nutrition for infants; it not only improves the neonatal intestinal function, but also regulates the immune system and gut microbiota composition. However, probiotic-fortified infant formula may further enhance the infant gut environment by overcoming the limitations of traditional infant formula. We investigated the probiotic formula administration for one month by comparing 118 Korean infants into the following three groups: infants in each group fed with breast milk (50), probiotic formula (35), or placebo formula-fed group (33). Probiotic formula improved stool consistency and defecation frequency compared to placebo formula-fed group. The probiotic formula helped maintaining the level of secretory immunoglobulin A (sIgA), which had remarkably decreased over time in placebo formula-fed infants (compared to weeks 0 and 4). Moreover, probiotic formula decreased the acidity of stool and considerably increased the butyrate concentration. Furthermore, the fecal microbiota of each group was evaluated at weeks 0 and 4. The microbial composition was distinct between each groups, and the abundance of health-promoting bacteria increased in the probiotic formula compared to the placebo formula-fed group. In summary, supplementation of probiotic infant formula can help optimize the infant gut environment, microbial composition, and metabolic activity of the microbiota, mimicking those of breast milk.
Identifiants
pubmed: 37484007
doi: 10.5851/kosfa.2023.e26
pii: kosfa-43-4-659
pmc: PMC10359846
doi:
Types de publication
Journal Article
Langues
eng
Pagination
659-673Informations de copyright
© Korean Society for Food Science of Animal Resources.
Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest.
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