Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.
Journal
RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460
Informations de publication
Date de publication:
20 Jul 2023
20 Jul 2023
Historique:
received:
22
03
2023
accepted:
29
04
2023
pmc-release:
02
06
2024
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
HIV-1 capsid (CA) is an attractive target for its indispensable roles in the viral life cycle. We report the design, synthesis, and mechanistic study of a novel series of 2-piperazineone peptidomimetics as HIV capsid modulators by mimicking the structure of host factors binding to CA. F-Id-3o was the most potent compound from the synthesized series, with an anti-HIV-1 EC
Identifiants
pubmed: 37484571
doi: 10.1039/d3md00134b
pii: d3md00134b
pmc: PMC10357934
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1272-1295Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150491
Pays : United States
Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
J Appl Toxicol. 2014 Aug;34(8):810-24
pubmed: 24532466
J Virol. 1995 Nov;69(11):6705-11
pubmed: 7474080
Nature. 2011 Jan 20;469(7330):424-7
pubmed: 21248851
ChemMedChem. 2008 Jun;3(6):885-97
pubmed: 18384086
Viruses. 2021 Dec 14;13(12):
pubmed: 34960770
J Virol. 2012 Aug;86(16):8472-81
pubmed: 22647699
Science. 2020 Oct 16;370(6514):360-364
pubmed: 33060363
Nature. 1999 Feb 4;397(6718):436-41
pubmed: 9989410
Acta Pharm Sin B. 2021 Mar;11(3):810-822
pubmed: 33777683
Chem Biodivers. 2009 Nov;6(11):2144-51
pubmed: 19937845
Eur J Med Chem. 2021 Dec 15;226:113848
pubmed: 34592608
Eur J Med Chem. 2018 Oct 5;158:478-492
pubmed: 30243152
ChemMedChem. 2013 Mar;8(3):426-32
pubmed: 23361947
PLoS Pathog. 2013;9(10):e1003693
pubmed: 24130490
Mutat Res. 1984 Sep-Nov;134(2-3):113-42
pubmed: 6390190
Aquat Toxicol. 2019 Dec;217:105345
pubmed: 31715477
J Control Release. 2014 Oct 28;192:271-83
pubmed: 25119469
Bioorg Med Chem Lett. 2014 Dec 1;24(23):5439-45
pubmed: 25454268
Biochemistry. 2016 May 10;55(18):2539-52
pubmed: 27074418
Biophys Rev. 2022 Jan 11;14(1):23-32
pubmed: 35340594
J Virol. 2007 May;81(10):5325-30
pubmed: 17329334
J Chem Inf Model. 2016 Nov 28;56(11):2180-2193
pubmed: 27753488
J Comput Aided Mol Des. 2018 Apr;32(4):537-546
pubmed: 29464466
Molecules. 2020 Mar 21;25(6):
pubmed: 32245167
Chem Sci. 2018 Jan 31;9(10):2655-2665
pubmed: 29719674
Mutat Res. 1986 Feb;164(1):9-17
pubmed: 2419751
Eur J Med Chem. 2022 Feb 5;229:114078
pubmed: 34992041
Nat Microbiol. 2021 Apr;6(4):435-444
pubmed: 33649557
Nature. 2020 Aug;584(7822):614-618
pubmed: 32612233
Retrovirology. 2016 Apr 23;13:28
pubmed: 27107820
Science. 1994 Sep 9;265(5178):1587-90
pubmed: 7915856
PLoS Pathog. 2010 Dec 09;6(12):e1001220
pubmed: 21170360
Virology. 1995 Feb 1;206(2):935-44
pubmed: 7531918
Viruses. 2021 Jul 22;13(8):
pubmed: 34452291
Retrovirology. 2021 Oct 26;18(1):32
pubmed: 34702294
J Med Chem. 2021 Apr 8;64(7):3747-3766
pubmed: 33750123
Nature. 2016 Aug 18;536(7616):349-53
pubmed: 27509857
J Virol. 2007 Apr;81(7):3645-8
pubmed: 17251295
J Virol. 2013 May;87(10):5372-83
pubmed: 23468492
J Drug Des Res. 2018;5(2):
pubmed: 30393786
Acta Pharm Sin B. 2022 Apr;12(4):1567-1590
pubmed: 35847492
Int J Cancer. 2008 May 1;122(9):1958-65
pubmed: 18183586
J Med Chem. 2022 Mar 10;65(5):3729-3757
pubmed: 35175760
Viruses. 2022 Feb 26;14(3):
pubmed: 35336885
Molecules. 2018 Aug 03;23(8):
pubmed: 30081466
Chem Soc Rev. 2021 Apr 7;50(7):4514-4540
pubmed: 33595031
J Toxicol Environ Health. 1997 Oct 10;52(2):137-48
pubmed: 9310146
J Gastroenterol Hepatol. 2012 Jun;27(6):1102-5
pubmed: 22142375
J Virol. 1997 Oct;71(10):7478-87
pubmed: 9311827
J Virol. 1996 Jun;70(6):3617-27
pubmed: 8648696
Eur J Med Chem. 2021 May 5;217:113380
pubmed: 33751981
J Med Chem. 2016 May 12;59(9):4210-20
pubmed: 26371436
Virology. 2019 Jun;532:118-126
pubmed: 31071616
PLoS Pathog. 2021 Sep 20;17(9):e1009484
pubmed: 34543344
RSC Adv. 2019;9(50):28961-28986
pubmed: 32089839
Viruses. 2021 Mar 15;13(3):
pubmed: 33804121
Bioorg Med Chem Lett. 2016 Feb 1;26(3):824-828
pubmed: 26747394
Future Med Chem. 2022 May;14(9):605-607
pubmed: 35297282
Protein Expr Purif. 2005 May;41(1):207-34
pubmed: 15915565
Elife. 2019 Jan 23;8:
pubmed: 30672737