A rare presentation of a spinal diffuse midline glioma in a child: a case report.
Diffuse midline glioma
H3K27 altered
case report
child
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
03
2023
accepted:
07
04
2023
medline:
25
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
Our patient had an extremely rare type of pediatric Diffuse Midline Glioma (DMG) with modified H3 K27 that occurred in the cervical spinal cord. Due to its location in the spinal cord, slow clinical presentation with torticollis for 7 months, and the non-specific radiological appearance of this tumour, it was initially considered to be a low-grade glioma. Based on imaging findings, the neurosurgery team performed a complete surgical resection, but the pathological features were consistent with a high-grade, diffuse midline glioma. Therefore, we are reporting a case of an altered high-grade DMG H3K27 glioma, which is difficult to diagnose due to its slow clinical symptoms which caused a delay in diagnosis, non-specific imaging, and with difficulty in accessing histopathological markers in low and middle income countries (LMIC).
Identifiants
pubmed: 37484594
doi: 10.11604/pamj.2023.44.183.39885
pii: PAMJ-44-183
pmc: PMC10362656
doi:
Substances chimiques
Histones
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
183Informations de copyright
Copyright: Zineb Isfaoun et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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