Can postoperative complications be reduced by the application of ERAS protocols in operated non-small cell lung cancer patients?
Complication
ERAS protocols
non-small cell lung cancer
thoracic surgery
Journal
Turk gogus kalp damar cerrahisi dergisi
ISSN: 1301-5680
Titre abrégé: Turk Gogus Kalp Damar Cerrahisi Derg
Pays: Turkey
ID NLM: 100887967
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
01
03
2022
accepted:
11
05
2022
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
In our study, we aimed to evaluate the length of hospital stay and complication rate of patients before and after application o f t he E nhanced R ecovery A fter S urgery ( ERAS) protocols. Between January 2001 and January 2021, a total of 845 patients (687 males, 158 females; mean age: 55±11 years; range, 19 to 89 years) who were operated with the diagnosis of non-small cell lung carcinoma were retrospectively analyzed. The patients were divided into three groups as follows: patients between 2001 and 2010 were evaluated as pre-ERAS (Group 1, n=285), patients between 2011 and 2015 as preparation for ERAS period (Group 2, n=269), and patients who had resection between 2016 and 2021 as the ERAS period (Group 3, n=291). All three groups were similar in terms of clinical, surgical and demographic characteristics. Smoking history was statistically significantly less in Group 3 (p=0.005). The forced expiratory volume in 1 sec/forced vital capacity and albumin levels were statistically significantly higher in Group 3 (p<0.001 and p=0.019, respectively). The leukocyte count and tumor maximum standardized uptake value were statistically significantly higher in Group 1 (p=0.018 and p=0.014, respectively). Postoperative hospitalization day, complication rate, and intensive care hospitalization rates were statistically significantly lower in Group 3 (p<0.001). The rate of additional disease was statistically significantly higher in Group 1 (p=0.030). Albumin level (<2.8 g/dL), lymphocyte/monocyte ratio (<1.35), and hemoglobin level (<8.3 g/dL) were found to be significant predictors of complication development. With the application of ERAS protocols, length of postoperative hospital stay, complication rate, and the need for intensive care hospitalization decrease. Preoperative hemoglobin level, albumin level, and lymphocyte/monocyte ratio are the predictors of complication development. Increasing hemoglobin and albumin levels before operation may reduce postoperative complications.
Sections du résumé
Background
UNASSIGNED
In our study, we aimed to evaluate the length of hospital stay and complication rate of patients before and after application o f t he E nhanced R ecovery A fter S urgery ( ERAS) protocols.
Methods
UNASSIGNED
Between January 2001 and January 2021, a total of 845 patients (687 males, 158 females; mean age: 55±11 years; range, 19 to 89 years) who were operated with the diagnosis of non-small cell lung carcinoma were retrospectively analyzed. The patients were divided into three groups as follows: patients between 2001 and 2010 were evaluated as pre-ERAS (Group 1, n=285), patients between 2011 and 2015 as preparation for ERAS period (Group 2, n=269), and patients who had resection between 2016 and 2021 as the ERAS period (Group 3, n=291).
Results
UNASSIGNED
All three groups were similar in terms of clinical, surgical and demographic characteristics. Smoking history was statistically significantly less in Group 3 (p=0.005). The forced expiratory volume in 1 sec/forced vital capacity and albumin levels were statistically significantly higher in Group 3 (p<0.001 and p=0.019, respectively). The leukocyte count and tumor maximum standardized uptake value were statistically significantly higher in Group 1 (p=0.018 and p=0.014, respectively). Postoperative hospitalization day, complication rate, and intensive care hospitalization rates were statistically significantly lower in Group 3 (p<0.001). The rate of additional disease was statistically significantly higher in Group 1 (p=0.030). Albumin level (<2.8 g/dL), lymphocyte/monocyte ratio (<1.35), and hemoglobin level (<8.3 g/dL) were found to be significant predictors of complication development.
Conclusion
UNASSIGNED
With the application of ERAS protocols, length of postoperative hospital stay, complication rate, and the need for intensive care hospitalization decrease. Preoperative hemoglobin level, albumin level, and lymphocyte/monocyte ratio are the predictors of complication development. Increasing hemoglobin and albumin levels before operation may reduce postoperative complications.
Identifiants
pubmed: 37484631
doi: 10.5606/tgkdc.dergisi.2023.23514
pmc: PMC10357847
doi:
Types de publication
Journal Article
Langues
eng
Pagination
256-268Informations de copyright
Copyright © 2023, Turkish Society of Cardiovascular Surgery.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
Références
Br J Surg. 2013 Jul;100(8):1108-14
pubmed: 23754650
J Thorac Cardiovasc Surg. 2021 Sep;162(3):710-720.e1
pubmed: 32713631
J Thorac Cardiovasc Surg. 2017 Dec;154(6):2084-2090
pubmed: 28728783
JAMA Surg. 2017 Mar 1;152(3):292-298
pubmed: 28097305
Semin Thorac Cardiovasc Surg. 2018 Autumn;30(3):342-349
pubmed: 29940227
Future Oncol. 2018 Mar;14(6s):33-40
pubmed: 29400559
J Thorac Dis. 2018 Mar;10(Suppl 4):S512-S516
pubmed: 29629197
Ann Thorac Surg. 2021 Mar;111(3):1036-1043
pubmed: 32805268
J Thorac Cardiovasc Surg. 2016 Mar;151(3):708-715.e6
pubmed: 26553460
Ann Thorac Surg. 2017 Sep;104(3):950-957
pubmed: 28778343
Thorac Cardiovasc Surg. 2022 Aug;70(5):405-412
pubmed: 34176111
J Vis Surg. 2018 Jan 05;4:4
pubmed: 29445590
J Thorac Dis. 2019 Apr;11(Suppl 7):S976-S986
pubmed: 31183180
Eur J Cardiothorac Surg. 2019 Jan 1;55(1):91-115
pubmed: 30304509
Lung Cancer. 2012 Feb;75(2):223-7
pubmed: 21764477
Zentralbl Chir. 2022 Sep;147(S 01):S21-S28
pubmed: 35235992
J Thorac Dis. 2018 Aug;10(Suppl 22):S2593-S2600
pubmed: 30345096
Br J Surg. 2015 Dec;102(13):1676-83
pubmed: 26492489