Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn.
K196E
ductus arteriosus aneurysm
protein S deficiency
thrombophilia
Journal
AJP reports
ISSN: 2157-6998
Titre abrégé: AJP Rep
Pays: United States
ID NLM: 101569862
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
07
03
2023
accepted:
10
05
2023
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
Ductus arteriosus aneurysm (DAA) asymptomatically occurs in newborn infants and resolves spontaneously. High-risk DAA with compression, rupture, and thrombosis requires early surgical intervention. Newborn infants have the highest risk of thrombosis among pediatric patients, but the genetic predisposition is difficult to determine in infancy. We herein report a neonatal case of massive thromboses in DAA and pulmonary artery. Desaturation occurred in an active full-term infant 2 days after birth. Echocardiography and contrast-enhanced computed tomography indicated thrombotic occlusion of the DAA and pulmonary artery thrombus. Urgent thrombectomy and ductus resection were successfully performed. After 6 months of anticoagulant therapy, the dissociated low plasma activity levels of protein S from protein C suggested protein S deficiency. A genetic study of
Identifiants
pubmed: 37484829
doi: 10.1055/a-2101-7738
pii: AJPR-23-Mar-0005
pmc: PMC10361822
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e44-e48Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).
Déclaration de conflit d'intérêts
Conflict of Interest None declared.
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