The secretome as a biomarker and functional agent in heart failure.
Secretome
biomarker
circulating microRNA
circulating protein
heart failure
Journal
The journal of cardiovascular aging
ISSN: 2768-5993
Titre abrégé: J Cardiovasc Aging
Pays: United States
ID NLM: 101778645
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
ppublish
Résumé
Heart failure (HF) is a complex and multifactorial disease. Recent advances have been made in understanding the underlying molecular processes involved in HF pathogenesis. These scientific advancements have brought to light the importance of the secretome. This paper presents a thorough overview of the state of science regarding the secretome's involvement in the onset, progression, and possibility of improved diagnosis and therapeutic interventions in HF. We explore the various types of secreted factors, including novel proteins, growth factors, cytokines, and microRNAs. We also discuss how they affect cellular signaling, angiogenesis, fibrosis, pathological cardiac remodeling, and inflammation in HF. Furthermore, we examine the role of the secretome in cardioprotection and cardiotoxicity. This review emphasizes the potential of the secretome for biomarker discovery. This might enable better HF diagnosis, risk stratification, monitoring and treatment. The review also discusses the difficulties on investigating the role of secreted factors and novel directions on secretome research. It highlights its potential as a target for novel therapeutic approaches and biomarker development.
Identifiants
pubmed: 37484982
doi: 10.20517/jca.2023.15
pmc: PMC10361342
mid: NIHMS1908037
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : K24 HL150630
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest Both authors declared that there are no conflicts of interest.
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