Replication stress by MMS stimulates DNA synthesis in post-replicative G2-phase in
Journal
microPublication biology
ISSN: 2578-9430
Titre abrégé: MicroPubl Biol
Pays: United States
ID NLM: 101759238
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
05
2023
revised:
16
06
2023
accepted:
05
07
2023
medline:
24
7
2023
pubmed:
24
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
DNA replication is generally limited to S-phase but replication stress can drive cells to undergo DNA synthesis outside of S-phase. Mitotic DNA synthesis pathway is known to be activated to deal with replication stress-induced chromosomal instability. There is also growing evidence that residual DNA synthesis can occur in G2. We demonstrate that fission yeast cells stimulate DNA synthesis in G2-phase but not in M-phase in response to DNA alkylating agent MMS. Auxin-induced degradation of DNA replication helicase Mcm4 during G2, but not during mitosis, inhibits post-replicative DNA synthesis.
Identifiants
pubmed: 37485020
doi: 10.17912/micropub.biology.000852
pmc: PMC10359921
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright: © 2023 by the authors.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest present.