Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review.
antibacterial strategies
mesenchymal stem cells
regeneration
regenerative endodontic procedures
scoping review
tissue engineering
Journal
International endodontic journal
ISSN: 1365-2591
Titre abrégé: Int Endod J
Pays: England
ID NLM: 8004996
Informations de publication
Date de publication:
23 Jul 2023
23 Jul 2023
Historique:
revised:
17
07
2023
received:
23
04
2023
accepted:
18
07
2023
pubmed:
24
7
2023
medline:
24
7
2023
entrez:
24
7
2023
Statut:
aheadofprint
Résumé
The clinical results following regenerative endodontic procedures (REPs) vary according to numerous parameters, including the presence of bacteria. This limitation reduces the indications for REPs and calls for the development of next generation antibacterial strategies (NGAS) providing alternatives to current antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP) and (Ca(OH)2). The present scoping review aims to describe the current trends regarding the use of such strategies and highlight future perspectives. Four databases (PUBMed, Cochrane, ClinicalTrials and Science Direct) were searched until 1st May 2023. A total of 918 records were identified, 133 were screened and assessed for eligibility, and 87 articles were included. The findings show that (1) clinical studies are only available for CAS, (2) although next generation strategies are the most studied approach since 2017, they are all at the pre-clinical stage, (3) most of the next generation strategies use galenic forms which offer cell support and colonization and which simultaneously contain antibacterial molecules as alternatives to CAS and to antibiotics in general, (4) standardization is required for future research, specifically regarding the bacterial strains studied, the use of biofilm studies and the cellular behaviour assessments. Although NGAS are promising strategies to improve REPs in the context of infection, the current evidence is mostly limited to pre-clinical studies. Further methodological improvement is required to allow relevant comparisons between studies and to reduce the time from bench to bedside.
Sections du résumé
BACKGROUND
BACKGROUND
The clinical results following regenerative endodontic procedures (REPs) vary according to numerous parameters, including the presence of bacteria. This limitation reduces the indications for REPs and calls for the development of next generation antibacterial strategies (NGAS) providing alternatives to current antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP) and (Ca(OH)2).
OBJECTIVES
OBJECTIVE
The present scoping review aims to describe the current trends regarding the use of such strategies and highlight future perspectives.
METHODS
METHODS
Four databases (PUBMed, Cochrane, ClinicalTrials and Science Direct) were searched until 1st May 2023.
RESULTS
RESULTS
A total of 918 records were identified, 133 were screened and assessed for eligibility, and 87 articles were included. The findings show that (1) clinical studies are only available for CAS, (2) although next generation strategies are the most studied approach since 2017, they are all at the pre-clinical stage, (3) most of the next generation strategies use galenic forms which offer cell support and colonization and which simultaneously contain antibacterial molecules as alternatives to CAS and to antibiotics in general, (4) standardization is required for future research, specifically regarding the bacterial strains studied, the use of biofilm studies and the cellular behaviour assessments.
CONCLUSION
CONCLUSIONS
Although NGAS are promising strategies to improve REPs in the context of infection, the current evidence is mostly limited to pre-clinical studies. Further methodological improvement is required to allow relevant comparisons between studies and to reduce the time from bench to bedside.
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-21CE19-0001
Organisme : Agence Nationale de la Recherche
ID : ANR-21 CE44-0015
Organisme : Centre National de la Recherche Scientifique
Organisme : Fondation de l'Avenir pour la Recherche Médicale Appliquée
ID : AP-RM-21-030
Organisme : Institut Français pour la Recherche Odontologique
Informations de copyright
© 2023 The Authors. International Endodontic Journal published by John Wiley & Sons Ltd on behalf of British Endodontic Society.
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