DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine.

Humans Medicine, Chinese Traditional Drugs, Chinese Herbal / pharmacology Databases, Factual

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
14 08 2023
Historique:
medline: 15 8 2023
pubmed: 24 7 2023
entrez: 24 7 2023
Statut: ppublish

Résumé

Traditional Chinese medicine (TCM) not only maintains the health of Asian people but also provides a great resource of active natural products for modern drug development. Herein, we developed a Database of Constituents Absorbed into the Blood and Metabolites of TCM (DCABM-TCM), the first database systematically collecting blood constituents of TCM prescriptions and herbs, including prototypes and metabolites experimentally detected in the blood, together with the corresponding detailed detection conditions through manual literature mining. The DCABM-TCM has collected 1816 blood constituents with chemical structures of 192 prescriptions and 194 herbs and integrated their related annotations, including physicochemical, absorption, distribution, metabolism, excretion, and toxicity properties, and associated targets, pathways, and diseases. Furthermore, the DCABM-TCM supported two blood constituent-based analysis functions, the network pharmacology analysis for TCM molecular mechanism elucidation, and the target/pathway/disease-based screening of candidate blood constituents, herbs, or prescriptions for TCM-based drug discovery. The DCABM-TCM is freely accessible at http://bionet.ncpsb.org.cn/dcabm-tcm/. The DCABM-TCM will contribute to the elucidation of effective constituents and molecular mechanism of TCMs and the discovery of TCM-derived drug-like compounds that are both bioactive and bioavailable.

Identifiants

DOI: 10.1021/acs.jcim.3c00365 PMID: 37486750 PMC: PMC10428213
pubmed: 37486750
doi: 10.1021/acs.jcim.3c00365
pmc: PMC10428213
doi:

Substances chimiques

Drugs, Chinese Herbal 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4948-4959

Références

Nucleic Acids Res. 2022 Jan 7;50(D1):D1324-D1333
pubmed: 34664659
ACS Omega. 2023 Feb 23;8(9):8827-8845
pubmed: 36910986
Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4826-31
pubmed: 18344322
Nucleic Acids Res. 2019 Jan 8;47(D1):D976-D982
pubmed: 30365030
Nucleic Acids Res. 2020 Jan 8;48(D1):D1031-D1041
pubmed: 31691823
BMC Complement Altern Med. 2015 Jul 09;15:218
pubmed: 26156871
BMC Complement Altern Med. 2019 Aug 14;19(1):212
pubmed: 31412866
Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082
pubmed: 29126136
Nucleic Acids Res. 2023 Jan 6;51(D1):D1288-D1299
pubmed: 36243961
Nucleic Acids Res. 2021 Jan 8;49(D1):D1233-D1243
pubmed: 33045737
Nucleic Acids Res. 2019 Jan 8;47(D1):D1102-D1109
pubmed: 30371825
J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):689-92
pubmed: 16902965
J Cheminform. 2013 May 31;5(1):28
pubmed: 23721660
Nature. 2011 Dec 21;480(7378):S82-3
pubmed: 22190085
PLoS One. 2015 Nov 10;10(11):e0142624
pubmed: 26555441
Drug Discov Today. 2016 May;21(5):712-7
pubmed: 26891978
Nucleic Acids Res. 2015 Jan;43(Database issue):D789-98
pubmed: 25428349
Nucleic Acids Res. 2018 Jan 4;46(D1):D1068-D1073
pubmed: 29156001
Nucleic Acids Res. 2011 Jan;39(Database issue):D52-7
pubmed: 21115458
Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275
pubmed: 36243960
J Cheminform. 2016 Nov 4;8:61
pubmed: 27867422
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
Br J Pharmacol. 2006 Dec;149(8):1092-103
pubmed: 17088869
Nat Biotechnol. 2015 Mar;33(3):264-8
pubmed: 25748918
PLoS One. 2011 Jan 06;6(1):e15939
pubmed: 21253603
Nucleic Acids Res. 2017 Jan 4;45(D1):D769-D776
pubmed: 27924021
Am J Cancer Res. 2020 Mar 01;10(3):727-742
pubmed: 32266087
J Cheminform. 2011 Oct 07;3:33
pubmed: 21982300
Nucleic Acids Res. 2018 Jan 4;46(D1):D1117-D1120
pubmed: 29106634
Comput Struct Biotechnol J. 2018 Nov 23;16:600-610
pubmed: 30546860
J Comput Chem. 2011 May;32(7):1466-74
pubmed: 21425294
J Chem Inf Model. 2007 Nov-Dec;47(6):2140-8
pubmed: 17985865
J Chem Inf Model. 2012 Nov 26;52(11):3099-105
pubmed: 23092397
Methods Mol Biol. 2007;406:89-112
pubmed: 18287689
J Cheminform. 2014 Apr 16;6:13
pubmed: 24735618
Nucleic Acids Res. 2008 Jan;36(Database issue):D344-50
pubmed: 17932057
Nucleic Acids Res. 2019 Jan 8;47(D1):D1110-D1117
pubmed: 30380087
Sci Rep. 2017 Jun 6;7(1):2821
pubmed: 28588237
Sci Rep. 2016 Feb 16;6:21146
pubmed: 26879404
Nucleic Acids Res. 2019 Jan 8;47(D1):D1118-D1127
pubmed: 30357356
Nucleic Acids Res. 2022 Jan 7;50(D1):D1417-D1431
pubmed: 34747471

Auteurs

Xinyue Liu (X)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Jinying Liu (J)

College of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.

Bangze Fu (B)

School of Biomedicine, Beijing City University, Beijing 100094, China.

Ruzhen Chen (R)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Jianzhou Jiang (J)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
School of Life Sciences, Hebei University, Baoding 071002, China.

He Chen (H)

School of Life Sciences, Hebei University, Baoding 071002, China.

Runa Li (R)

School of Biomedicine, Beijing City University, Beijing 100094, China.

Lin Xing (L)

School of Biomedicine, Beijing City University, Beijing 100094, China.

Liying Yuan (L)

School of Life Sciences, Hebei University, Baoding 071002, China.

Xuetai Chen (X)

School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Jing Zhang (J)

School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Honglei Li (H)

Beijing Cloudna Technology Company, Limited, Beijing 100029, China.

Shuzhen Guo (S)

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
ORCID: 0000-0002-8980-9812

Feifei Guo (F)

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Jiachen Guo (J)

School of Life Sciences, Hebei University, Baoding 071002, China.

Yuan Liu (Y)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Yaning Qi (Y)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Biyue Yu (B)

School of Life Sciences, Hebei University, Baoding 071002, China.

Feng Xu (F)

School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Dong Li (D)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Zhongyang Liu (Z)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
School of Life Sciences, Hebei University, Baoding 071002, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DCABM-TCM: A Database of Constituents Absorbed...
questionsmedicales.fr › Sciences sociales › Anthropologie › Anthropologie culturelle › Médecine traditionnelle › Médecine traditionnelle d'Asie orientale › Médecine traditionnelle chinoise › DCABM-TCM: A Database of Constituents Absorbed...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments issus de plantes chinoises › DCABM-TCM: A Database of Constituents Absorbed...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › DCABM-TCM: A Database of Constituents Absorbed...