Taurocholate uptake by Caco-2 cells is inhibited by pro-inflammatory cytokines and butyrate.
Butyrate
Caco-2 cells
IFN-γ
TNF-α
Taurocholate uptake
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
01
06
2023
revised:
13
07
2023
accepted:
18
07
2023
medline:
11
8
2023
pubmed:
25
7
2023
entrez:
24
7
2023
Statut:
ppublish
Résumé
Inflammatory bowel disease (IBD) is a group of chronic and life-threating inflammatory diseases of the gastrointestinal tract. The active intestinal absorption of bile salts is reduced in IBD, resulting in higher luminal concentrations of these agents that contribute to the pathophysiology of IBD-associated diarrhea. Butyrate (BT) is a short-chain fatty acid produced by colonic bacterial fermentation of dietary fibers. BT utilization is impaired in the intestinal inflamed mucosa of IBD patients. Our aim was to investigate the link between IBD and bile acid absorption, by testing the effect of the pro-inflammatory cytokines TNF-α and IFN-γ and of BT upon
Identifiants
pubmed: 37487380
pii: S1043-4666(23)00185-0
doi: 10.1016/j.cyto.2023.156307
pii:
doi:
Substances chimiques
Cytokines
0
Tumor Necrosis Factor-alpha
0
Butyrates
0
Taurocholic Acid
5E090O0G3Z
Bile Acids and Salts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
156307Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mafalda Couto reports financial support was provided by GEDDI (BuSBY project).