Global analysis of putative phospholipases in
Animals
Humans
Plasmodium falciparum
/ metabolism
Parasites
/ metabolism
Phosphoinositide Phospholipase C
/ metabolism
Phospholipases
/ genetics
Protozoan Proteins
/ genetics
Malaria
/ metabolism
Phospholipids
/ metabolism
Phosphatidylinositols
/ metabolism
Erythrocytes
/ parasitology
Malaria, Falciparum
/ parasitology
blood stage
malaria
phosphoinositides
phospholipase
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
medline:
4
9
2023
pubmed:
25
7
2023
entrez:
25
7
2023
Statut:
ppublish
Résumé
For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, using reverse genetics approaches, we show that only 1 out of the 19 putative phospholipases expressed in asexual blood stages of
Identifiants
pubmed: 37489900
doi: 10.1128/mbio.01413-23
pmc: PMC10470789
doi:
Substances chimiques
Phosphoinositide Phospholipase C
EC 3.1.4.11
Phospholipases
EC 3.1.-
Protozoan Proteins
0
Phospholipids
0
Phosphatidylinositols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0141323Subventions
Organisme : Wellcome Trust
ID : FC001043
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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