The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation.
Atherosclerosis
Cardiovascular disease
Endothelial cells (ECs)
Mechanical stimulation
Piezo1
Journal
Genes & diseases
ISSN: 2352-3042
Titre abrégé: Genes Dis
Pays: Netherlands
ID NLM: 101635967
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
03
11
2021
accepted:
12
08
2022
medline:
26
7
2023
pubmed:
26
7
2023
entrez:
26
7
2023
Statut:
epublish
Résumé
In recent years, cardiovascular health problems are becoming more and more serious. At the same time, mechanical stimulation closely relates to cardiovascular health. In this context, Piezo1, which is very sensitive to mechanical stimulation, has attracted our attention. Here, we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells, NO production, lipid metabolism, DNA damage protection, the development of new blood vessels and maturation, narrowing of blood vessels, blood pressure regulation, vascular permeability, insulin sensitivity, and maintenance of red blood cell function. Besides, Piezo1 may participate in the occurrence and development of atherosclerosis, diabetes, hypertension, and other cardiovascular diseases. It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health. On the one hand, the function of Piezo1 is necessary to maintain cardiovascular health; on the other hand, under some extreme mechanical stimulation, the overexpression of Piezo1 may bring adverse factors such as inflammation. Therefore, this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1.
Identifiants
pubmed: 37492728
doi: 10.1016/j.gendis.2022.08.015
pii: S2352-3042(22)00236-7
pmc: PMC10363580
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1956-1968Informations de copyright
© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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