ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant

Humans Rifabutin / pharmacology Mycobacterium Infections, Nontuberculous / drug therapy Mycobacterium abscessus Anti-Bacterial Agents / pharmacology Rifamycins Microbial Sensitivity Tests
ADP-ribosylase NTM caseum drug tolerance non-tuberculous mycobacteria persistence rifamycins

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
19 09 2023
Historique:
medline: 20 9 2023
pubmed: 26 7 2023
entrez: 26 7 2023
Statut: ppublish

Résumé

Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary

Identifiants

DOI: 10.1128/aac.00381-23 PMID: 37493373 PMC: PMC10508146
pubmed: 37493373
doi: 10.1128/aac.00381-23
pmc: PMC10508146
doi:

Substances chimiques

Rifabutin 1W306TDA6S
Anti-Bacterial Agents 0
Rifamycins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0038123

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132374
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142731
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Min Xie (M)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.

Uday S Ganapathy (US)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.

Tian Lan (T)

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.

Paulina Osiecki (P)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.

Jansy P Sarathy (JP)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.

Véronique Dartois (V)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA.

Courtney C Aldrich (CC)

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.

Thomas Dick (T)

Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA.
Department of Microbiology and Immunology, Georgetown University , Washington, District of Columbia, USA.
ORCID: 0000-0002-9604-9452

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › Rifabutine › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Infections à mycobactéries non tuberculeuses › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobactéries non tuberculeuses › Mycobacterium abscessus › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › ADP-ribosylation-resistant rifabutin analogs...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › ADP-ribosylation-resistant rifabutin analogs...