Rapid home therapy infusion of velaglucerase alfa in naïve patients with Gaucher disease.

Gaucher disease LysoGb1 enzyme replacement therapy, ERT glucocerebrosidase home therapy rapid infusion

Journal

Internal medicine journal
ISSN: 1445-5994
Titre abrégé: Intern Med J
Pays: Australia
ID NLM: 101092952

Informations de publication

Date de publication:
26 Jul 2023
Historique:
received: 15 02 2023
accepted: 18 06 2023
medline: 26 7 2023
pubmed: 26 7 2023
entrez: 26 7 2023
Statut: aheadofprint

Résumé

Enzyme replacement therapy (ERT) has revolutionised the management of patients with Gaucher disease (GD). In 2018, we published the safety and efficacy of rapid 10-min infusion of velaglucerase alfa in previously treated patients, mostly on low-dose therapy. To improve quality of life (QoL) for patients needing lifelong bi-weekly infusions by introducing a 10-min infusion instead of 1 h per label in patients naive to ERT and on high-dose therapy. Fifteen naive patients were enrolled; all received bi-weekly infusions of 60 units/kgBW velaglucerase alfa; the infusion rate was gradually reduced in the hospital, followed by home infusions. Each infusion was followed for safety. Efficacy parameters were assessed every 3 months. Patient-reported outcome questionnaires were collected at baseline and follow-up. Ten-minute rapid infusions were well tolerated without related severe adverse events (SAEs). Two patients experienced a non-related SAE and another a possibly related AE. In three patients, the infusion rate was increased to 30 or 60 min (two because of suboptimal response and one because of AE). Two patients dropped out because of an unwillingness to attend follow-up visits during the COVID-19 pandemic. All 13 remaining patients reached the 24-month end-point. The platelet counts increased by a median (range) of 68.38% (12.5-300%) and the lyso-Gb1 levels decreased by 62.6% (32.9-89.9%). Home therapy with rapid infusion of high-dose velaglucerase alfa was a safe, effective and preferable alternative for patients with GD naïve to treatment. We believe that shortening the infusion time improves the QoL of patients with GD who have a lifelong commitment to intravenous therapy.

Sections du résumé

BACKGROUND BACKGROUND
Enzyme replacement therapy (ERT) has revolutionised the management of patients with Gaucher disease (GD). In 2018, we published the safety and efficacy of rapid 10-min infusion of velaglucerase alfa in previously treated patients, mostly on low-dose therapy.
AIM OBJECTIVE
To improve quality of life (QoL) for patients needing lifelong bi-weekly infusions by introducing a 10-min infusion instead of 1 h per label in patients naive to ERT and on high-dose therapy.
METHODS METHODS
Fifteen naive patients were enrolled; all received bi-weekly infusions of 60 units/kgBW velaglucerase alfa; the infusion rate was gradually reduced in the hospital, followed by home infusions. Each infusion was followed for safety. Efficacy parameters were assessed every 3 months. Patient-reported outcome questionnaires were collected at baseline and follow-up.
RESULTS RESULTS
Ten-minute rapid infusions were well tolerated without related severe adverse events (SAEs). Two patients experienced a non-related SAE and another a possibly related AE. In three patients, the infusion rate was increased to 30 or 60 min (two because of suboptimal response and one because of AE). Two patients dropped out because of an unwillingness to attend follow-up visits during the COVID-19 pandemic. All 13 remaining patients reached the 24-month end-point. The platelet counts increased by a median (range) of 68.38% (12.5-300%) and the lyso-Gb1 levels decreased by 62.6% (32.9-89.9%).
CONCLUSION CONCLUSIONS
Home therapy with rapid infusion of high-dose velaglucerase alfa was a safe, effective and preferable alternative for patients with GD naïve to treatment. We believe that shortening the infusion time improves the QoL of patients with GD who have a lifelong commitment to intravenous therapy.

Identifiants

pubmed: 37493453
doi: 10.1111/imj.16179
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Takeda Pharmaceutical Company

Informations de copyright

© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.

Références

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Auteurs

Michal Becker-Cohen (M)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.

Shoshana Revel-Vilk (S)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Dafna Frydman (D)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.

Tama Dinur (T)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.

Maayan Tiomkin (M)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.

Majdolen Istaiti (M)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.

Naama Arbel (N)

Medison Pharma, Petah Tikva, Israel.

Peter Bauer (P)

Centogene AG, Rostock, Germany.

Claudia Cozma (C)

Centogene AG, Rostock, Germany.

Arndt Rolfs (A)

Department of Neurology and Psychiatry, Medical Faculty, University of Rostock, Rostock, Germany.
Arcensus GmbH, Rostock, Germany.

Jeff Szer (J)

Peter MacCallum Cancer Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Ari Zimran (A)

Gaucher Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Classifications MeSH