Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
28 07 2023
28 07 2023
Historique:
medline:
28
7
2023
pubmed:
26
7
2023
entrez:
26
7
2023
Statut:
ppublish
Résumé
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of cell death and a substrate of Caspase-8. However, the physiological role of cFLIP cleavage by Caspase-8 remains elusive. Here, we found an essential role for cFLIP cleavage in restraining cell death in different pathophysiological scenarios. Mice expressing a cleavage-resistant cFLIP mutant,
Identifiants
pubmed: 37494451
doi: 10.1126/sciadv.adg2829
pmc: PMC10371024
doi:
Substances chimiques
Caspase 8
EC 3.4.22.-
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg2829Subventions
Organisme : Cancer Research UK
ID : 24399
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00025/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00811X/1
Pays : United Kingdom
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