Fabrication of a protein-dextran conjugates formed oral nanoemulsion and its application to deliver the essential oil from Alpinia zerumbet Fructus.

Mice Animals Alpinia Oils, Volatile / pharmacology Endothelial Cells Dextrans / pharmacology Fruit Emulsions / pharmacology
Essential oil from Alpinia zerumbet Fructus (EOFAZ) Proteoglycan based nanoemulsion Vascular endothelial injury

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
30 Sep 2023
Historique:
received: 28 01 2023
revised: 04 07 2023
accepted: 18 07 2023
medline: 27 9 2023
pubmed: 27 7 2023
entrez: 26 7 2023
Statut: ppublish

Résumé

The injury of vascular endothelial cells caused by high glucose (HG) is one of the driving factors of vascular complications of diabetes. Oral administration is the most common route of administration for the treatment of diabetes and its vascular complications. Essential oil extracts from Chinese medicine possess potential therapeutic effects on vascular endothelial injury. However, low solubility and volatility of essential oils generally result in poor oral absorption. Development of nanocarriers for essential oils is a promising strategy to overcome the physiological barriers of oral absorption. In this study, a nanoemulsion composed of bovine serum albumin (BSA)-dextran sulfate (DS) conjugate and sodium deoxycholate (SD) was constructed. The nanoemulsions were verified with promoted oral absorption and prolonged circulation time. After the primary evaluation of the nanoemulsion, essential oil from Alpinia zerumbet Fructus (EOFAZ)-loaded nanoemulsion (denoted as EOFAZ@BD

Identifiants

DOI: 10.1016/j.ijbiomac.2023.125918 PMID: 37495002
pubmed: 37495002
pii: S0141-8130(23)02813-1
doi: 10.1016/j.ijbiomac.2023.125918
pii:
doi:

Substances chimiques

Oils, Volatile 0
Dextrans 0
Emulsions 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

125918

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declared no competing interests.

Auteurs

Jinzhuan Xu (J)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Zhaohui Jiang (Z)

The First People's Hospital of Guiyang, Guiyang 550002, China.

Jianqing Peng (J)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Runbin Sun (R)

Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.

Lili Zhang (L)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Yan Chen (Y)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Di Pan (D)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Jing Huang (J)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.

Zipeng Gong (Z)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China. Electronic address: gzp4012607@126.com.

Yi Chen (Y)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China. Electronic address: chenyi_19890319@126.com.

Xiangchun Shen (X)

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China. Electronic address: shenxiangchun@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Eucaryotes › Animaux › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Zingiberales › Zingiberaceae › Alpinia › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Lipides › Huiles › Huile essentielle › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Aliments et boissons › Aliments › Fruit › Fabrication of a protein-dextran conjugates...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Fabrication of a protein-dextran conjugates...