Evolutionary modeling suggests that addictions may be driven by competition-induced microbiome dysbiosis.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
26 07 2023
Historique:
received: 16 03 2022
accepted: 05 07 2023
medline: 28 7 2023
pubmed: 27 7 2023
entrez: 26 7 2023
Statut: epublish

Résumé

Recent studies revealed mechanisms by which the microbiome affects its host's brain, behavior and wellbeing, and that dysbiosis - persistent microbiome-imbalance - is associated with the onset and progress of various chronic diseases, including addictive behaviors. Yet, understanding of the ecological and evolutionary processes that shape the host-microbiome ecosystem and affect the host state, is still limited. Here we propose that competition dynamics within the microbiome, associated with host-microbiome mutual regulation, may promote dysbiosis and aggravate addictive behaviors. We construct a mathematical framework, modeling the dynamics of the host-microbiome ecosystem in response to alterations. We find that when this ecosystem is exposed to substantial perturbations, the microbiome may shift towards a composition that reinforces the new host state. Such a positive feedback loop augments post-perturbation imbalances, hindering attempts to return to the initial equilibrium, promoting relapse episodes and prolonging addictions. We show that the initial microbiome composition is a key factor: a diverse microbiome enhances the ecosystem's resilience, whereas lower microbiome diversity is more prone to lead to dysbiosis, exacerbating addictions. This framework provides evolutionary and ecological perspectives on host-microbiome interactions and their implications for host behavior and health, while offering verifiable predictions with potential relevance to clinical treatments.

Identifiants

pubmed: 37495841
doi: 10.1038/s42003-023-05099-0
pii: 10.1038/s42003-023-05099-0
pmc: PMC10372008
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

782

Informations de copyright

© 2023. The Author(s).

Références

NCHS Data Brief. 2021 Dec;(426):1-8
pubmed: 34978529
Nat Commun. 2022 Aug 8;13(1):4630
pubmed: 35941112
Neuropharmacology. 2018 Oct;141:249-259
pubmed: 30172845
Rep Prog Phys. 2018 Jan;81(1):012602
pubmed: 29051394
Sci Rep. 2019 Feb 4;9(1):1363
pubmed: 30718608
Neuropsychopharmacology. 2022 Sep;47(10):1739-1745
pubmed: 34750568
Cell Host Microbe. 2018 Jun 13;23(6):716-724
pubmed: 29902437
Nat Commun. 2017 Jan 12;8:14040
pubmed: 28079112
Mucosal Immunol. 2016 Nov;9(6):1418-1428
pubmed: 26906406
Gut. 2021 Mar;70(3):595-605
pubmed: 33051190
Commun Biol. 2023 Jul 26;6(1):782
pubmed: 37495841
Sci Transl Med. 2014 Nov 19;6(263):263ra158
pubmed: 25411471
Pharmaceuticals (Basel). 2018 Jun 25;11(3):
pubmed: 29941795
SSM Popul Health. 2019 Jan 11;7:100349
pubmed: 30723766
Science. 2019 Nov 1;366(6465):
pubmed: 31672864
Nature. 1972 Aug 18;238(5364):413-4
pubmed: 4559589
Sci Rep. 2018 Feb 26;8(1):3596
pubmed: 29483538
Philos Trans R Soc Lond B Biol Sci. 2020 Sep 28;375(1808):20190599
pubmed: 32772664
Neurosci Biobehav Rev. 2016 Sep;68:370-386
pubmed: 27235078
Science. 2015 Nov 6;350(6261):663-6
pubmed: 26542567
Alcohol Res. 2015;37(2):223-36
pubmed: 26695747
Proc Biol Sci. 2020 Feb 12;287(1920):20192754
pubmed: 32075531
Nutr Res. 2020 May;77:62-72
pubmed: 32330749
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4485-93
pubmed: 25288760
Brain Behav Immun. 2012 Aug;26(6):911-8
pubmed: 22521198
J Evol Biol. 2010 Jun 1;23(6):1245-50
pubmed: 20345809
Sci Adv. 2021 Nov 05;7(45):eabi7159
pubmed: 34739314
J Psychiatr Res. 2018 Sep;104:130-136
pubmed: 30029052
Science. 2019 Sep 27;365(6460):1405-1409
pubmed: 31604267
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20591-20597
pubmed: 31548380
Mol Psychiatry. 2016 Jun;21(6):797-805
pubmed: 27090302
Front Endocrinol (Lausanne). 2020 Jan 31;11:25
pubmed: 32082260
Cell Host Microbe. 2015 May 13;17(5):565-76
pubmed: 25974299
J Clin Med. 2018 Sep 14;7(9):
pubmed: 30223529
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Addiction. 2018 Oct;113(10):1905-1926
pubmed: 29749059
Clin Sci (Lond). 2022 Sep 30;136(18):1371-1387
pubmed: 36156126
Nat Ecol Evol. 2022 Jun;6(6):693-700
pubmed: 35484221
Science. 2019 Jun 14;364(6445):
pubmed: 31196984
Curr Biol. 2019 Jun 3;29(11):R538-R544
pubmed: 31163167
Transl Psychiatry. 2017 Feb 28;7(2):e1048
pubmed: 28244981
Neuroimage. 2015 Apr 1;109:95-101
pubmed: 25562824
BMC Evol Biol. 2017 Jun 17;17(1):143
pubmed: 28623896
PLoS Comput Biol. 2013;9(12):e1003388
pubmed: 24348232
Nature. 2016 Jul 06;535(7610):65-74
pubmed: 27383981
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5970-5
pubmed: 27140646
Drug Alcohol Depend. 1999 Jul 1;55(3):209-24
pubmed: 10428362
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Mol Cell. 2020 May 21;78(4):577-583
pubmed: 32275853
Behav Pharmacol. 2020 Apr;31(2&3):113-121
pubmed: 31895059
Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):655-672
pubmed: 32855515
Neuropsychopharmacology. 2018 Dec;43(13):2606-2614
pubmed: 30258112
Gut Microbes. 2015;6(6):388-91
pubmed: 26727422
PLoS One. 2017 Sep 1;12(9):e0183509
pubmed: 28863139
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13523-13532
pubmed: 31209039
Aliment Pharmacol Ther. 2017 Jan;45(2):319-331
pubmed: 27868217
Sci Adv. 2019 Feb 06;5(2):eaau8317
pubmed: 30775438
Proc Biol Sci. 2013 May 01;280(1761):20130400
pubmed: 23760639
Behav Brain Res. 2017 Apr 14;323:172-176
pubmed: 28161446
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
Nature. 2021 Dec;600(7890):713-719
pubmed: 34880502
Science. 2012 Oct 19;338(6105):344-8
pubmed: 23087241
Nature. 2019 Apr;568(7753):499-504
pubmed: 30745586
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Arch Microbiol. 2018 Jul;200(5):677-684
pubmed: 29626219
Nat Ecol Evol. 2020 Mar;4(3):366-375
pubmed: 32042125
Psychopharmacology (Berl). 2019 May;236(5):1611-1622
pubmed: 31098656
BMJ Glob Health. 2022 Sep;7(9):
pubmed: 36130777
Neurogastroenterol Motil. 2022 Oct;34(10):e14346
pubmed: 35246905
Adv Nutr. 2020 May 1;11(3):709-723
pubmed: 31825083
Sci Rep. 2020 Aug 24;10(1):14112
pubmed: 32839473
Sci Rep. 2016 Oct 18;6:35455
pubmed: 27752130
Elife. 2013 Dec 17;2:e01169
pubmed: 24347543
Nat Rev Immunol. 2009 May;9(5):313-23
pubmed: 19343057
Curr Opin Microbiol. 2020 Feb;53:19-25
pubmed: 32088581
Psychopharmacology (Berl). 2019 May;236(5):1513-1530
pubmed: 30982128
MMWR Morb Mortal Wkly Rep. 2020 Oct 02;69(39):1428-1433
pubmed: 33001874
Cell. 2016 Jan 28;164(3):337-40
pubmed: 26824647
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
N Engl J Med. 2016 Jan 28;374(4):363-71
pubmed: 26816013
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11951-E11960
pubmed: 30510004
Curr Psychiatry Rep. 2018 Mar 5;20(2):8
pubmed: 29504045
Neurosci Biobehav Rev. 2019 Nov;106:245-262
pubmed: 30227143
Am J Prev Med. 2015 Nov;49(5):e73-e79
pubmed: 26477807
Psychoneuroendocrinology. 2016 Jan;63:217-27
pubmed: 26479188

Auteurs

Ohad Lewin-Epstein (O)

School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, 6997801, Israel. ohadletaz@gmail.com.
Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. ohadletaz@gmail.com.
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. ohadletaz@gmail.com.

Yanabah Jaques (Y)

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA.

Marcus W Feldman (MW)

Department of Biology, Stanford University, Stanford, CA, 94305, USA.

Daniela Kaufer (D)

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA.
Department of Integrative Biology, University of California, Berkeley, CA, 94720, USA.

Lilach Hadany (L)

School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, 6997801, Israel. lilach.hadany@gmail.com.
Sagol school of neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel. lilach.hadany@gmail.com.

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