Adrenal Anion Channels: New Roles in Zona Glomerulosa Physiology and in the Pathophysiology of Primary Aldosteronism.

Aldosterone CLCN2 Chloride channel ClC-2 Oscillation

Journal

Handbook of experimental pharmacology

ISSN: 0171-2004

Titre abrégé: Handb Exp Pharmacol

Pays: Germany

ID NLM: 7902231

Informations de publication

Date de publication:
27 Jul 2023

Historique:

medline: 27 7 2023

pubmed: 27 7 2023

entrez: 26 7 2023

Statut: aheadofprint

Résumé

The mineralocorticoid aldosterone is produced in the zona glomerulosa of the adrenal cortex. Its synthesis is regulated by the serum concentrations of the peptide hormone angiotensin II and potassium. The primary role of aldosterone is to control blood volume and electrolytes. The autonomous production of aldosterone (primary aldosteronism, PA) is considered the most frequent cause of secondary hypertension. Aldosterone-producing adenomas and (micro-)nodules are frequent causes of PA and often carry somatic mutations in ion channels and transporters. Rare familial forms of PA are due to germline mutations. Both somatic and germline mutations in the chloride channel gene CLCN2, encoding ClC-2, have been identified in PA. Clinical findings and results from cell culture and animal models have advanced our knowledge about the role of anions in PA. The zona glomerulosa of the adrenal gland has now been firmly established as a tissue in which anions play a significant role for signaling. In this overview, we aim to summarize the current knowledge and highlight novel concepts as well as open questions.

Identifiants

DOI: 10.1007/164_2023_680 PMID: 37495852

pubmed: 37495852

doi: 10.1007/164_2023_680

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

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