Ketogenic dietary therapies in epilepsy: recommendations of the Italian League against Epilepsy Dietary Therapy Study Group.

Ketogenic dietary therapies consensus drug resistant epilepsy multidisciplinary approach recommendations target treatment

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2023
Historique:
received: 02 05 2023
accepted: 24 05 2023
medline: 27 7 2023
pubmed: 27 7 2023
entrez: 27 7 2023
Statut: epublish

Résumé

A stepwise increase in the utilization of ketogenic dietary therapies for drug-resistant epilepsy has been observed in Italy in the last decade, although it is still considered often underused in many centers when compared to other countries. The Dietary Therapy Study Group of the Italian League against Epilepsy proposes practical recommendations to improve shared knowledge and facilitate the application of ketogenic dietary therapies, optimizing its efficacy and tolerability. The experts involved (11 child neuropsychiatrists, two adult neurologists, one psychologist, one pharmacologist, one pediatric endocrinologist, one representative of patients' associations, and three dietitians and clinical nutritionists) responded to a survey on current clinical practice issues and were asked to discuss controversial topics related to supplementation, long-term maintenance, transition, and a multidisciplinary approach to ketogenic dietary therapies. Practical indications for patient selection, diet initiation, management, side effects prevention, and follow-up are provided.

Identifiants

pubmed: 37497012
doi: 10.3389/fneur.2023.1215618
pmc: PMC10368245
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1215618

Informations de copyright

Copyright © 2023 De Giorgis, Tagliabue, Bisulli, Brambilla, Camerini, Cusmai, Darra, Dianin, Domenica, Lodi, Matricardi, Messana, Operto, Ragona, Russo, Varesio, Volpi, Zanaboni, Pasca and Veggiotti.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Valentina De Giorgis (V)

Department of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.

Anna Tagliabue (A)

Department of Public Health, Human Nutrition and Eating Disorder Research Center and Ketogenic Metabolic Therapy Laboratory-Experimental and Forensic Medicine University of Pavia, Pavia, Italy.

Francesca Bisulli (F)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the European Reference Network for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Ilaria Brambilla (I)

Endocrinologia, Diabetologia e Ginecologia Pediatrica, Fondazione IRCCS Policlinico San Matteo di Pavia, Università degli Studi di Pavia, Pavia, Italy.

Alessandra Camerini (A)

Italian GLUT1-DS Association, Milan, Italy.

Raffaella Cusmai (R)

Child Neurology Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.

Francesca Darra (F)

Child Neuropsychiatry Unit, Department of Engineering for Innovation Medicine, University of Verona, Full Member of European Reference Network EpiCARE, Verona, Italy.

Alice Dianin (A)

Inherited Metabolic Diseases Unit and Regional Centre for Newborn Screening, Diagnosis and Treatment of Inherited Metabolic Diseases and Congenital Endocrine Diseases, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Elia Domenica (E)

Artificial Nutrition Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Monica Anna Maria Lodi (MAM)

Department of Child Neuropsychiatry, Epilepsy Center, Fatebenefratelli Hospital, Milan, Italy.

Sara Matricardi (S)

Department of Pediatrics, University of Chieti, Chieti, Italy.

Tullio Messana (T)

Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'etá pediatrica, Member of the ERN Epicare, Bologna, Italy.

Francesca Operto (F)

Department of Science of Health, School of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Francesca Ragona (F)

Department of Pediatric Neurology, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.

Emilio Russo (E)

Science of Health Department, University of Catanzaro, Catanzaro, Italy.

Costanza Varesio (C)

Department of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.

Lilia Volpi (L)

UOC Neurologia, IRCCS Istituto delle Scienze Neurologiche, Azienda USL di Bologna, Ospedale Bellaria Bologna, Bologna, Italy.

Martina Paola Zanaboni (MP)

Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.

Ludovica Pasca (L)

Department of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.

Pierangelo Veggiotti (P)

Vittore Buzzi Children's Hospital, Pediatric Neurology Unit, Milan, Italy.
Department of Biomedical and Clinical Sciences, L. Sacco, University of Milan, Milan, Italy.

Classifications MeSH