D-Serine as a sensor and effector of the kidney.
Chronic kidney disease
D-Asparagine
D-Serine
D-Serine clearance
Diabetes
Glomerular filtration rate
Kidney transplantation
Journal
Clinical and experimental nephrology
ISSN: 1437-7799
Titre abrégé: Clin Exp Nephrol
Pays: Japan
ID NLM: 9709923
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
24
04
2023
accepted:
11
07
2023
medline:
23
10
2023
pubmed:
27
7
2023
entrez:
27
7
2023
Statut:
ppublish
Résumé
D-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of D-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance. D-Serine also has a direct effect on the kidneys and mediates the cellular proliferation of tubular cells via mTOR signaling and induces kidney remodeling as a compensatory reaction to the loss of kidney mass. In living kidney donors, the removal of the kidney results in an increase in blood D-serine level, which in turn accelerates kidney remodeling and augments kidney clearance, thus reducing blood levels of D-serine. This feedback system strictly controls D-serine levels in the body. The function of D-serine as a biomarker and modulator of kidney function will be the basis of precision medicine for kidney diseases.
Identifiants
pubmed: 37498348
doi: 10.1007/s10157-023-02384-4
pii: 10.1007/s10157-023-02384-4
pmc: PMC10582142
doi:
Substances chimiques
Serine
452VLY9402
Creatinine
AYI8EX34EU
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
891-900Subventions
Organisme : Japan Society for the Promotion of Science
ID : 21H02935
Organisme : Japan Agency for Medical Research and Development
ID : JP21gm5010001
Informations de copyright
© 2023. The Author(s).
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