Fentanyl and the Fluorinated Fentanyl Derivative NFEPP Elicit Distinct Hydrogen-Bond Dynamics of the Opioid Receptor.

Humans Fentanyl / pharmacology Receptors, Opioid Analgesics, Opioid / pharmacology Receptors, Opioid, mu / metabolism Pain Hydrogen

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
14 08 2023
Historique:
medline: 15 8 2023
pubmed: 27 7 2023
entrez: 27 7 2023
Statut: ppublish

Résumé

The development of safe therapeutics to manage pain is of central interest for biomedical applications. The fluorinated fentanyl derivative

Identifiants

DOI: 10.1021/acs.jcim.3c00197 PMID: 37498626
pubmed: 37498626
doi: 10.1021/acs.jcim.3c00197
doi:

Substances chimiques

Fentanyl UF599785JZ
Receptors, Opioid 0
Analgesics, Opioid 0
Receptors, Opioid, mu 0
Hydrogen 7YNJ3PO35Z

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4732-4748

Auteurs

Samo Lešnik (S)

Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia.
Institute for Environmental Protection and Sensors, Beloruska ulica 7, 2000 Maribor, Slovenia.
ORCID: 0000-0002-0613-6959

Urban Bren (U)

Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia.
Institute for Environmental Protection and Sensors, Beloruska ulica 7, 2000 Maribor, Slovenia.
Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, SI-6000 Koper, Slovenia.
ORCID: 0000-0002-8806-3019

Tatiana Domratcheva (T)

Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Department of Biomolecular Mechanisms, Max-Plank-Institute fur Medizinische Forschung, D-69120 Heidelberg, Germany.
ORCID: 0000-0002-7001-1114

Ana-Nicoleta Bondar (AN)

Faculty of Physics, University of Bucharest, Atomiştilor 405, 077125 Măgurele, Romania.
Institute of Computational Biomedicine, IAS-5/INM-9, Forschungszentrum Jülich, Wilhelm-Johnen Straße, 5428 Jülich, Germany.
ORCID: 0000-0003-2636-9773

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Fentanyl and the Fluorinated Fentanyl...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Hydrogène › Fentanyl and the Fluorinated Fentanyl...