Neural substrates for dissociation of cognition inhibition in autogenous- and reactive-type obsessive-compulsive disorder.

Humans Brain Mapping / methods Neural Pathways / diagnostic imaging Cognition Motor Cortex Obsessive-Compulsive Disorder / diagnostic imaging Magnetic Resonance Imaging / methods
Autogenous-reactive obsessions Cognition inhibition Functional connectivity Heterogeneity Response inhibition

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
09 2023
Historique:
received: 10 05 2023
revised: 13 07 2023
accepted: 20 07 2023
medline: 4 9 2023
pubmed: 28 7 2023
entrez: 27 7 2023
Statut: ppublish

Résumé

The taxonomy of autogenous- and reactive-type obsessive-compulsive disorder (OCD) (AO vs. RO) is one of the most valid subtyping approaches to the heterogeneity of OCD. The present study aimed to seek evidence of neural substrates supporting the dissociation of cognition inhibition in AO and RO which was revealed by our previous behavioral and electrophysiological work. A total of 165 patients with OCD (86 AO versus 79 RO), and 79 healthy controls (HC) underwent resting-state functional magnetic resonance imaging scans. Within-network connectivity, node strength, and edge-wise functional connectivity (FC) in cognition and response inhibition networks were calculated. Results from 3 cognition and 2 response inhibition network atlases were compared to confirm the robustness of the findings. Both AO and RO showed lower within-network connectivity in response inhibition networks, while lower within cognition inhibition network connectivity was only detected in AO. Besides shared weaker node strength in the anterior insula (AI), anterior cingulate cortex (ACC), and supplementary motor area (SMA), AO had a broader range of nodes within cognition inhibition networks exhibiting weaker strength, including nodes in right inferior frontal gyrus (IFG), left parietal and occipital regions. Decreased FC of left AI-CC, left IFG-ACC, and frontal-parietal regions in cognition inhibition networks were found in AO. Findings indicate that unlike deficits in connectivity within response inhibition networks which may reflect a common pathology in AO and RO, deficits in connectivity within cognition inhibition networks were more pronounced in AO. These findings strengthen our insight into the heterogeneity in OCD.

Sections du résumé

BACKGROUND
The taxonomy of autogenous- and reactive-type obsessive-compulsive disorder (OCD) (AO vs. RO) is one of the most valid subtyping approaches to the heterogeneity of OCD. The present study aimed to seek evidence of neural substrates supporting the dissociation of cognition inhibition in AO and RO which was revealed by our previous behavioral and electrophysiological work.
METHODS
A total of 165 patients with OCD (86 AO versus 79 RO), and 79 healthy controls (HC) underwent resting-state functional magnetic resonance imaging scans. Within-network connectivity, node strength, and edge-wise functional connectivity (FC) in cognition and response inhibition networks were calculated. Results from 3 cognition and 2 response inhibition network atlases were compared to confirm the robustness of the findings.
RESULTS
Both AO and RO showed lower within-network connectivity in response inhibition networks, while lower within cognition inhibition network connectivity was only detected in AO. Besides shared weaker node strength in the anterior insula (AI), anterior cingulate cortex (ACC), and supplementary motor area (SMA), AO had a broader range of nodes within cognition inhibition networks exhibiting weaker strength, including nodes in right inferior frontal gyrus (IFG), left parietal and occipital regions. Decreased FC of left AI-CC, left IFG-ACC, and frontal-parietal regions in cognition inhibition networks were found in AO.
CONCLUSIONS
Findings indicate that unlike deficits in connectivity within response inhibition networks which may reflect a common pathology in AO and RO, deficits in connectivity within cognition inhibition networks were more pronounced in AO. These findings strengthen our insight into the heterogeneity in OCD.

Identifiants

DOI: 10.1016/j.jpsychires.2023.07.031 PMID: 37499486
pubmed: 37499486
pii: S0022-3956(23)00383-7
doi: 10.1016/j.jpsychires.2023.07.031
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

150-157

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Jie Fan (J)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan, 410011, China; National Clinical Research Center for Mental Disorders, Changsha, 410011, Hunan, China; National Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Jie Xia (J)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Qian Liu (Q)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Xiang Wang (X)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Hongyu Du (H)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Feng Gao (F)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Yan Han (Y)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Quanhao Yu (Q)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Jingjie Lu (J)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Chuman Xiao (C)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Changlian Tan (C)

Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Xiongzhao Zhu (X)

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan, 410011, China; National Clinical Research Center for Mental Disorders, Changsha, 410011, Hunan, China; National Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. Electronic address: xiongzhaozhu@csu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neural substrates for dissociation of...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Neural substrates for dissociation of...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Neural substrates for dissociation of...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Neural substrates for dissociation of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › Neural substrates for dissociation of...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Neural substrates for dissociation of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Neural substrates for dissociation of...