Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.


Journal

Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278

Informations de publication

Date de publication:
09 2023
Historique:
revised: 21 06 2023
received: 14 04 2023
accepted: 09 07 2023
medline: 18 9 2023
pubmed: 28 7 2023
entrez: 28 7 2023
Statut: ppublish

Résumé

To explore filtered diffusion-weighted imaging (fDWI), in comparison with conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), as a predictor for long-term locomotor and urodynamic (UD) outcomes in Yucatan minipig model of spinal cord injury (SCI). Additionally, electrical conductivity of neural tissue using D-waves above and below the injury was measured to assess correlations between fDWI and D-waves data. Eleven minipigs with contusion SCI at T8-T10 level underwent MRI at 3T 4 h. post-SCI. Parameters extracted from region of interest analysis included D Two groups of pigs were found based on the PTIBS at week 12 (p < 0.0001) post-SCI and were labeled "poor" and "good" recovery. D-waves amplitude decreased below injury and increased above injury. UD outcomes pre/post SCI changed significantly. Conventional MRI metrics from T Similar to small animal studies, fDWI from acute imaging after SCI is a promising predictor for functional outcomes in large animals.

Identifiants

pubmed: 37501362
doi: 10.1002/acn3.51855
pmc: PMC10502634
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1647-1661

Subventions

Organisme : NINDS NIH HHS
ID : R21 NS114982
Pays : United States

Informations de copyright

© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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Auteurs

Rakib Uddin Ahmed (RU)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Daniel Medina-Aguinaga (D)

Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.

Shawns Adams (S)

Department of Neurosurgery, Duke University, Raleigh, North Carolina, USA.

Chase A Knibbe (CA)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Monique Morgan (M)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Destiny Gibson (D)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Joo-Won Kim (JW)

Department of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA.

Mayur Sharma (M)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Manpreet Chopra (M)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Steven Davison (S)

Comparative Medicine Research Unit, University of Louisville, Louisville, Kentucky, USA.

Leslie C Sherwood (LC)

Comparative Medicine Research Unit, University of Louisville, Louisville, Kentucky, USA.

M J Negahdar (MJ)

Department of Radiology, University of Louisville, Louisville, Kentucky, USA.

Robert Bert (R)

Department of Radiology, University of Louisville, Louisville, Kentucky, USA.

Beatrice Ugiliweneza (B)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

Charles Hubscher (C)

Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.

Matthew D Budde (MD)

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA.

Junqian Xu (J)

Department of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA.

Maxwell Boakye (M)

Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky, USA.

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