A scorpion toxin affecting sodium channels shows double cis-trans isomerism.
cis-peptide bond
neurotoxin
nuclear magnetic resonance
protein structure
venom
voltage-gated sodium channel
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
07
07
2023
accepted:
14
07
2023
medline:
23
10
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
Scorpion α-toxins (α-NaTx) inhibiting the inactivation of voltage-gated sodium channels (Na
Identifiants
pubmed: 37501371
doi: 10.1002/1873-3468.14705
doi:
Substances chimiques
Scorpion Venoms
0
Voltage-Gated Sodium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2358-2368Informations de copyright
© 2023 Federation of European Biochemical Societies.
Références
Bosmans F and Tytgat J (2007) Voltage-gated sodium channel modulation by scorpion alpha-toxins. Toxicon 49, 142-158.
Beneski DA and Catterall WA (1980) Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxin. Proc Natl Acad Sci USA 77, 639-643.
Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C et al. (2019) Structural basis of α-scorpion toxin action on Na(v) channels. Science 363, eaav8573.
Jalali A, Bosmans F, Amininasab M, Clynen E, Cuypers E, Zaremirakabadi A, Sarbolouki MN, Schoofs L, Vatanpour H and Tytgat J (2005) OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett 579, 4181-4186.
Alvarez P, Bogen O, Green PG and Levine JD (2021) Nociceptor overexpression of Na(V)1.7 contributes to chronic muscle pain induced by early-life stress. J Pain 22, 806-816.
Kuzmenkov AI, Grishin EV and Vassilevski AA (2015) Diversity of potassium channel ligands: focus on scorpion toxins. Biochemistry (Mosc) 80, 1764-1799.
Chugunov AO, Koromyslova AD, Berkut AA, Peigneur S, Tytgat J, Polyansky AA, Pentkovsky VM, Vassilevski AA, Grishin EV and Efremov RG (2013) Modular organization of alpha-toxins from scorpion venom mirrors domain structure of their targets, sodium channels. J Biol Chem 288, 19014-19027.
Ye X, Bosmans F, Li C, Zhang Y, Wang DC and Tytgat J (2005) Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1. J Mol Biol 353, 788-803.
Gordon D, Karbat I, Ilan N, Cohen L, Kahn R, Gilles N, Dong K, Stühmer W, Tytgat J and Gurevitz M (2007) The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. Toxicon 49, 452-472.
Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D and Gurevitz M (2009) Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem 284, 20684-20691.
Kuldyushev NA, Berkut AA, Peigneur S, Tytgat J, Grishin EV and Vassilevski AA (2017) Design of sodium channel ligands with defined selectivity - a case study in scorpion alpha-toxins. FEBS Lett 591, 3414-3420.
Torrance GM, Leader DP, Gilbert DR and Milner-White EJ (2009) A novel main chain motif in proteins bridged by cationic groups: the niche. J Mol Biol 385, 1076-1086.
Kuldyushev NA, Mineev KS, Berkut AA, Peigneur S, Arseniev AS, Tytgat J, Grishin EV and Vassilevski AA (2018) Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels. Proteins 86, 1117-1122.
Watson JD and Milner-White EJ (2002) A novel main-chain anion-binding site in proteins: the nest. A particular combination of phi,psi values in successive residues gives rise to anion-binding sites that occur commonly and are found often at functionally important regions. J Mol Biol 315, 171-182.
Mineev KS, Kuzmenkov AI, Arseniev AS and Vassilevski AA (2021) Structure of MeuNaTxα-1 toxin from scorpion venom highlights the importance of the nest motif. Proteins 89, 1055-1060.
Kopeyan C, Martinez G and Rochat H (1985) Primary structure of toxin IV of Leiurus quinquestriatus quinquestriatus. FEBS Lett 181, 211-217.
Pluzhnikov K, Vassilevski A, Korolkova Y, Fisyunov A, Iegorova O, Krishtal O and Grishin E (2007) Omega-Lsp-IA, a novel modulator of P-type Ca2+ channels. Toxicon 50, 993-1004.
McCoy J and La Ville E (2001) Expression and purification of thioredoxin fusion proteins. Curr Protoc Protein Sci Chapter 6, Unit 6.7.
Jeong H, Barbe V, Lee CH, Vallenet D, Yu DS, Choi SH, Couloux A, Lee SW, Yoon SH, Cattolico L et al. (2009) Genome sequences of Escherichia coli B strains REL606 and BL21(DE3). J Mol Biol 394, 644-652.
Block H, Maertens B, Spriestersbach A, Brinker N, Kubicek J, Fabis R, Labahn J and Schäfer F (2009) Immobilized-metal affinity chromatography (IMAC): a review. Methods Enzymol 463, 439-473.
Andreev YA, Kozlov SA, Vassilevski AA and Grishin EV (2010) Cyanogen bromide cleavage of proteins in salt and buffer solutions. Anal Biochem 407, 144-146.
Kuzmenkov AI, Sachkova MY, Kovalchuk SI, Grishin EV and Vassilevski AA (2016) Lachesana tarabaevi, an expert in membrane-active toxins. Biochem J 473, 2495-2506.
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., MacCallum, C. J., Macleod, M., … Würbel, H. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLOS Biology, 18(7), e3000410. https://doi.org/10.1371/journal.pbio.3000410
Pervushin K, Riek R, Wider G and Wüthrich K (1998) Transverse relaxation-optimized spectroscopy (TROSY) for NMR studies of aromatic spin systems in 13C-labeled proteins. J Am Chem Soc 120, 6394-6400.
Löhr F, Hänsel R, Rogov VV and Dötsch V (2007) Improved pulse sequences for sequence specific assignment of aromatic proton resonances in proteins. J Biomol NMR 37, 205-224.
Favier A and Brutscher B (2011) Recovering lost magnetization: polarization enhancement in biomolecular NMR. J Biomol NMR 49, 9-15.
Mayzel M, Kazimierczuk K and Orekhov VY (2014) The causality principle in the reconstruction of sparse NMR spectra. Chem Commun (Camb) 50, 8947-8950.
Güntert P and Buchner L (2015) Combined automated NOE assignment and structure calculation with CYANA. J Biomol NMR 62, 453-471.
Shen Y and Bax A (2015) Protein structural information derived from NMR chemical shift with the neural network program TALOS-N. Methods Mol Biol 1260, 17-32.
Vuister GW and Bax A (1993) Quantitative J correlation: a new approach for measuring homonuclear three-bond J(HNH.alpha.) coupling constants in 15N-enriched proteins. J Am Chem Soc 115, 7772-7777.
Düx P, Whitehead B, Boelens R, Kaptein R and Vuister GW (1997) Measurement of 15N-1H coupling constants in uniformly 15N-labeled proteins: application to the photoactive yellow protein. J Biomol NMR 10, 301-306.
Grzesiek S, Vuister GW and Bax A (1993) A simple and sensitive experiment for measurement of JCC couplings between backbone carbonyl and methyl carbons in isotopically enriched proteins. J Biomol NMR 3, 487-493.
Vuister GW, Wang AC and Bax A (1993) Measurement of three-bond nitrogen-carbon J couplings in proteins uniformly enriched in nitrogen-15 and carbon-13. J Am Chem Soc 115, 5334-5335.
Laskowski RA, Jabłońska J, Pravda L, Vařeková RS and Thornton JM (2018) PDBsum: structural summaries of PDB entries. Protein Sci 27, 129-134.
Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ and Alewood PF (2013) Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. ACS Chem Biol 8, 1215-1222.
van Cann M, Kuzmenkov A, Isensee J, Andreev-Andrievskiy A, Peigneur S, Khusainov G, Berkut A, Tytgat J, Vassilevski A and Hucho T (2021) Scorpion toxin MeuNaTxα-1 sensitizes primary nociceptors by selective modulation of voltage-gated sodium channels. FEBS J 288, 2418-2435.
Richardson JS, Getzoff ED and Richardson DC (1978) The beta bulge: a common small unit of nonrepetitive protein structure. Proc Natl Acad Sci USA 75, 2574-2578.
Schubert M, Labudde D, Oschkinat H and Schmieder P (2002) A software tool for the prediction of Xaa-pro peptide bond conformations in proteins based on 13C chemical shift statistics. J Biomol NMR 24, 149-154.
Jabs A, Weiss MS and Hilgenfeld R (1999) Non-proline cis peptide bonds in proteins. J Mol Biol 286, 291-304.
Wishart DS, Sykes BD and Richards FM (1991) Relationship between nuclear magnetic resonance chemical shift and protein secondary structure. J Mol Biol 222, 311-333.
Guan RJ, Xiang Y, He XL, Wang CG, Wang M, Zhang Y, Sundberg EJ and Wang DC (2004) Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins. J Mol Biol 341, 1189-1204.