A new mutation in the


Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2023
Historique:
received: 26 04 2023
accepted: 26 06 2023
medline: 31 7 2023
pubmed: 28 7 2023
entrez: 28 7 2023
Statut: epublish

Résumé

Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and may have a genetic background. Congenital generalized lipodystrophy type 4 (CGL4) is an extremely rare subtype, caused by mutations in the polymerase I and transcript release factor (

Identifiants

pubmed: 37501786
doi: 10.3389/fendo.2023.1212729
pmc: PMC10369054
doi:

Types de publication

Review Case Reports Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1212729

Informations de copyright

Copyright © 2023 Mancioppi, Daffara, Romanisio, Ceccarini, Pelosini, Santini, Bellone, Mellone, Baricich, Rabbone, Aimaretti, Akinci, Giordano and Prodam.

Déclaration de conflit d'intérêts

FP worked as a consultant for the following companies, which are involved with lipodystrophy and/or diabetes: Aegerion/Amryt Pharmaceuticals, Novo Nordisk. BA attended advisory board meetings organized by Amryt Pharmaceuticals and Regeneron Pharmaceuticals and has served as a consultant and/or received honoraria as a speaker from Third Rock Ventures, Amryt, Regeneron, AstraZeneca, Lilly, MSD, Novartis, Novo Nordisk, Boehringer-Ingelheim, Servier, and Sanofi-Aventis. GC has received fees for consulting and/or received travel funds or participated in studies from the following companies, which are involved with lipodystrophy and/or diabetes: Aegerion/Amryt Pharmaceuticals, Novo-Nordisk, and Rhythm Pharmaceuticals. SM received travel funds from the following company, which was involved with lipodystrophy: Amryt Pharmaceuticals. FS has worked as a consultant, participated in studies, and/or received travel funds from the following companies, which are involved with lipodystrophy and/or diabetes: Aegerion/Amryt, Novo Nordisk, Lilly, Bruno Pharma, and Pfizer. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Valentina Mancioppi (V)

Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Tommaso Daffara (T)

Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Martina Romanisio (M)

Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Giovanni Ceccarini (G)

Obesity and Lipodystrophy Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.

Caterina Pelosini (C)

Chemistry and Endocrinology Laboratory, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy.

Ferruccio Santini (F)

Obesity and Lipodystrophy Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.

Simonetta Bellone (S)

Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Interdisciplinary Research Center of Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy.

Simona Mellone (S)

Laboratory of Genetics, Struttura Complessa a Direzione Universitaria (SCDU) Biochimica Clinica, Ospedale Maggiore della Carità, Novara, Italy.

Alessio Baricich (A)

Physical Medicine and Rehabilitation, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Ivana Rabbone (I)

Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Gianluca Aimaretti (G)

Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Baris Akinci (B)

Division of Endocrinology and Metabolism, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.

Mara Giordano (M)

Laboratory of Genetics, Struttura Complessa a Direzione Universitaria (SCDU) Biochimica Clinica, Ospedale Maggiore della Carità, Novara, Italy.
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Flavia Prodam (F)

Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Interdisciplinary Research Center of Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy.

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